User:Dustin Soe/Sandbox 1
From Proteopedia
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==Introduction== | ==Introduction== | ||
[https://en.wikipedia.org/wiki/Lipoprotein_lipase LPL] is a part of the lipase family. [https://en.wikipedia.org/wiki/Lipase Lipases] are enzymes that is capable of catalyzing the hydrolysis of fats/lipids which are consumed through oils. It is encoded by the p22 region in chromosome 8. Once synthesized, it is secreted into the inter interstitial space in several tissues. The main site of action for LPL is in the capillary lumen within muscle and adipose tissue. | [https://en.wikipedia.org/wiki/Lipoprotein_lipase LPL] is a part of the lipase family. [https://en.wikipedia.org/wiki/Lipase Lipases] are enzymes that is capable of catalyzing the hydrolysis of fats/lipids which are consumed through oils. It is encoded by the p22 region in chromosome 8. Once synthesized, it is secreted into the inter interstitial space in several tissues. The main site of action for LPL is in the capillary lumen within muscle and adipose tissue. | ||
| - | [ | + | [[Image:LLP11.jpg|300 px|left|thumb|LPL Image]] |
== Function == | == Function == | ||
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== Relevance & Disease == | == Relevance & Disease == | ||
| - | LPL is an extremely important enzyme, in that it breaks down triglycerides carried on VLDL, which leads to the reduction of cholesterol buildup. Cholesterol build up is a very serious issue with regards to obesity in the United States. In addition to this, increased plasma triglyceride levels (hypertriglyceridemia) is very unhealthy and is the leading cause of Coronary Artery Disease in America. LPL is an enzyme that helps combat this disease by breaking down the excess triglycerides that block the arteries of your heart. Very similarly, Chylomicronemia, a high level of triglycerides in the blood, causes buildup of chylomicrons (ultra-low-density lipoproteins) and leads to similar diseases. Without LPL in the body, developing coronary & metabolic (liver & pancreas) based diseases are at a higher likelihood | + | LPL is an extremely important enzyme, in that it breaks down triglycerides carried on VLDL, which leads to the reduction of cholesterol buildup. Cholesterol build up is a very serious issue with regards to obesity in the United States. In addition to this, increased plasma triglyceride levels (hypertriglyceridemia) is very unhealthy and is the leading cause of Coronary Artery Disease in America. LPL is an enzyme that helps combat this disease by breaking down the excess triglycerides that block the arteries of your heart. Very similarly, Chylomicronemia, a high level of triglycerides in the blood, causes buildup of chylomicrons (ultra-low-density lipoproteins) and leads to similar diseases. Without LPL in the body, developing coronary & metabolic (liver & pancreas) based diseases are at a higher likelihood. [[Image:M404_No_Mutation_copy.jpg|300 px|right|thumb|No Mutation Image]] |
| + | [[Image:M404ToR404Pymol_copy_2.jpg|300 px|right|thumb|Mutation Image]] | ||
== Structural highlights == | == Structural highlights == | ||
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== References == | == References == | ||
Revision as of 19:54, 5 April 2021
Lipoprotein Lipase (LPL)
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