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7bu5
From Proteopedia
(Difference between revisions)
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| - | ==== | + | ==Crystal Structure of Human SLX4 and MUS81== |
| - | <StructureSection load='7bu5' size='340' side='right'caption='[[7bu5]]' scene=''> | + | <StructureSection load='7bu5' size='340' side='right'caption='[[7bu5]], [[Resolution|resolution]] 1.80Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol= FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[7bu5]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7BU5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7BU5 FirstGlance]. <br> |
| - | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7bu5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7bu5 OCA], [https://pdbe.org/7bu5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7bu5 RCSB], [https://www.ebi.ac.uk/pdbsum/7bu5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7bu5 ProSAT]</span></td></tr> | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8Å</td></tr> |
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GLY:GLYCINE'>GLY</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7bu5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7bu5 OCA], [https://pdbe.org/7bu5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7bu5 RCSB], [https://www.ebi.ac.uk/pdbsum/7bu5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7bu5 ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/MUS81_HUMAN MUS81_HUMAN] Interacts with EME1 and EME2 to form a DNA structure-specific endonuclease with substrate preference for branched DNA structures with a 5'-end at the branch nick. Typical substrates include 3'-flap structures, replication forks and nicked Holliday junctions. May be required in mitosis for the processing of stalled or collapsed replication forks.<ref>PMID:11741546</ref> <ref>PMID:12374758</ref> <ref>PMID:12686547</ref> <ref>PMID:12721304</ref> <ref>PMID:14617801</ref> <ref>PMID:15805243</ref> <ref>PMID:17289582</ref> <ref>PMID:19595721</ref> <ref>PMID:19596235</ref> | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: | + | [[Category: Lei M]] |
| + | [[Category: Wan B]] | ||
| + | [[Category: Wu J]] | ||
Current revision
Crystal Structure of Human SLX4 and MUS81
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Categories: Homo sapiens | Large Structures | Lei M | Wan B | Wu J
