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7kaa

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Current revision (11:13, 14 June 2023) (edit) (undo)
 
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==NMR solution structures of tirasemtiv drug bound to a fast skeletal troponin C-troponin I complex==
==NMR solution structures of tirasemtiv drug bound to a fast skeletal troponin C-troponin I complex==
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<StructureSection load='7kaa' size='340' side='right'caption='[[7kaa]], [[NMR_Ensembles_of_Models | 25 NMR models]]' scene=''>
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<StructureSection load='7kaa' size='340' side='right'caption='[[7kaa]]' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[7kaa]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7KAA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7KAA FirstGlance]. <br>
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<table><tr><td colspan='2'>[[7kaa]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7KAA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7KAA FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=W97:6-ethynyl-1-(pentan-3-yl)-1H-imidazo[4,5-b]pyrazin-2-ol'>W97</scene></td></tr>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=W97:6-ethynyl-1-(pentan-3-yl)-1H-imidazo[4,5-b]pyrazin-2-ol'>W97</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">TNNI2 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
 
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7kaa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7kaa OCA], [https://pdbe.org/7kaa PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7kaa RCSB], [https://www.ebi.ac.uk/pdbsum/7kaa PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7kaa ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7kaa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7kaa OCA], [https://pdbe.org/7kaa PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7kaa RCSB], [https://www.ebi.ac.uk/pdbsum/7kaa PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7kaa ProSAT]</span></td></tr>
</table>
</table>
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== Disease ==
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[https://www.uniprot.org/uniprot/TNNI2_HUMAN TNNI2_HUMAN] Sheldon-Hall syndrome;Digitotalar dysmorphism. The disease is caused by mutations affecting the gene represented in this entry.
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/TNNC2_HUMAN TNNC2_HUMAN]] Troponin is the central regulatory protein of striated muscle contraction. Tn consists of three components: Tn-I which is the inhibitor of actomyosin ATPase, Tn-T which contains the binding site for tropomyosin and Tn-C. The binding of calcium to Tn-C abolishes the inhibitory action of Tn on actin filaments.
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[https://www.uniprot.org/uniprot/TNNC2_HUMAN TNNC2_HUMAN] Troponin is the central regulatory protein of striated muscle contraction. Tn consists of three components: Tn-I which is the inhibitor of actomyosin ATPase, Tn-T which contains the binding site for tropomyosin and Tn-C. The binding of calcium to Tn-C abolishes the inhibitory action of Tn on actin filaments.[https://www.uniprot.org/uniprot/TNNI2_HUMAN TNNI2_HUMAN] Troponin I is the inhibitory subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 7kaa" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 7kaa" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Troponin 3D structures|Troponin 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Hartman, J J]]
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[[Category: Hartman JJ]]
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[[Category: Li, M X]]
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[[Category: Li MX]]
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[[Category: Mercier, P]]
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[[Category: Mercier P]]
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[[Category: Sykes, B D]]
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[[Category: Sykes BD]]
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[[Category: Activator]]
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[[Category: Contractile protein]]
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Current revision

NMR solution structures of tirasemtiv drug bound to a fast skeletal troponin C-troponin I complex

PDB ID 7kaa

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