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1ijf

From Proteopedia

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Current revision (08:34, 16 August 2023) (edit) (undo)
 
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<StructureSection load='1ijf' size='340' side='right'caption='[[1ijf]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
<StructureSection load='1ijf' size='340' side='right'caption='[[1ijf]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[1ijf]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/ ] and [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1IJF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1IJF FirstGlance]. <br>
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<table><tr><td colspan='2'>[[1ijf]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1IJF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1IJF FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1f60|1f60]], [[1g7c|1g7c]], [[1ije|1ije]]</div></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ijf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ijf OCA], [https://pdbe.org/1ijf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ijf RCSB], [https://www.ebi.ac.uk/pdbsum/1ijf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ijf ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ijf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ijf OCA], [https://pdbe.org/1ijf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ijf RCSB], [https://www.ebi.ac.uk/pdbsum/1ijf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ijf ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/EF1B_YEAST EF1B_YEAST]] Catalytic subunit of the guanine nucleotide exchange factor (GEF) (eEF1B subcomplex) of the eukaryotic elongation factor 1 complex (eEF1). Stimulates the exchange of GDP for GTP on elongation factor 1A (eEF1A), probably by displacing GDP from the nucleotide binding pocket in eEF1A. The 30-fold higher concentration of GTP compared to GDP in cells favors the formation of eEF1A-GTP, which rapidly forms a ternary complex with aminoacyl-tRNA that in turn displaces eEF1B from the complex.<ref>PMID:10409717</ref>
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[https://www.uniprot.org/uniprot/EF1A_YEAST EF1A_YEAST]
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Saccharomyces cerevisiae]]
[[Category: Saccharomyces cerevisiae]]
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[[Category: Andersen, G R]]
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[[Category: Andersen GR]]
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[[Category: Kinzy, T G]]
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[[Category: Kinzy TG]]
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[[Category: Nyborg, J]]
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[[Category: Nyborg J]]
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[[Category: Pedersen, L]]
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[[Category: Pedersen L]]
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[[Category: Valente, L]]
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[[Category: Valente L]]
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[[Category: Protein complex]]
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[[Category: Translation]]
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Current revision

Nucleotide exchange mechanisms in the eEF1A-eEF1Ba complex

PDB ID 1ijf

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