2juf

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Current revision (19:05, 29 May 2024) (edit) (undo)
 
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==NMR solution structure of PARC CPH Domain. NESG Target HR3443B/SGC-Toronto==
==NMR solution structure of PARC CPH Domain. NESG Target HR3443B/SGC-Toronto==
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<StructureSection load='2juf' size='340' side='right'caption='[[2juf]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
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<StructureSection load='2juf' size='340' side='right'caption='[[2juf]]' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2juf]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JUF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2JUF FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2juf]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JUF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2JUF FirstGlance]. <br>
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</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">PARC, H7AP1, KIAA0708 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2juf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2juf OCA], [https://pdbe.org/2juf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2juf RCSB], [https://www.ebi.ac.uk/pdbsum/2juf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2juf ProSAT], [https://www.topsan.org/Proteins/NESGC/2juf TOPSAN]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2juf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2juf OCA], [https://pdbe.org/2juf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2juf RCSB], [https://www.ebi.ac.uk/pdbsum/2juf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2juf ProSAT], [https://www.topsan.org/Proteins/NESGC/2juf TOPSAN]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/CUL9_HUMAN CUL9_HUMAN]] Core component of a Cul9-RING ubiquitin-protein ligase complex, a complex that mediates ubiquitination and subsequent degradation of BIRC5 and is required to maintain microtubule dynamics and genome integrity. Acts downstream of the 3M complex, which inhibits CUL9 activity, leading to prevent ubiquitination of BIRC5 (PubMed:24793696). Cytoplasmic anchor protein in p53/TP53-associated protein complex. Regulates the subcellular localization of p53/TP53 and subsequent function (PubMed:12526791, PubMed:17332328).<ref>PMID:12526791</ref> <ref>PMID:17332328</ref> <ref>PMID:24793696</ref>
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[https://www.uniprot.org/uniprot/CUL9_HUMAN CUL9_HUMAN] Core component of a Cul9-RING ubiquitin-protein ligase complex, a complex that mediates ubiquitination and subsequent degradation of BIRC5 and is required to maintain microtubule dynamics and genome integrity. Acts downstream of the 3M complex, which inhibits CUL9 activity, leading to prevent ubiquitination of BIRC5 (PubMed:24793696). Cytoplasmic anchor protein in p53/TP53-associated protein complex. Regulates the subcellular localization of p53/TP53 and subsequent function (PubMed:12526791, PubMed:17332328).<ref>PMID:12526791</ref> <ref>PMID:17332328</ref> <ref>PMID:24793696</ref>
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Arrowsmith, C H]]
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[[Category: Arrowsmith CH]]
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[[Category: Dhe-Paganon, S]]
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[[Category: Dhe-Paganon S]]
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[[Category: Duan, S]]
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[[Category: Duan S]]
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[[Category: Edwards, A M]]
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[[Category: Edwards AM]]
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[[Category: Karra, M]]
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[[Category: Karra M]]
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[[Category: Kaustov, L]]
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[[Category: Kaustov L]]
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[[Category: Lemak, S]]
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[[Category: Lemak S]]
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[[Category: Liao, J C.C]]
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[[Category: Liao JCC]]
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[[Category: Muhandiram, R]]
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[[Category: Muhandiram R]]
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[[Category: Structural genomic]]
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[[Category: Srisailam SH]]
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[[Category: Srisailam, S H]]
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[[Category: Sundstrom M]]
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[[Category: Sundstrom, M]]
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[[Category: Weigelt J]]
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[[Category: Weigelt, J]]
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[[Category: Alternative splicing]]
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[[Category: Atp-binding]]
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[[Category: Coiled coil]]
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[[Category: Cph domain]]
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[[Category: Cytoplasm]]
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[[Category: Gene regulation]]
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[[Category: Metal-binding]]
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[[Category: Nesg]]
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[[Category: Nucleotide-binding]]
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[[Category: PSI, Protein structure initiative]]
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[[Category: Sgc]]
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[[Category: Ubl conjugation]]
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[[Category: Ubl conjugation pathway]]
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[[Category: Zinc]]
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[[Category: Zinc-finger]]
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Current revision

NMR solution structure of PARC CPH Domain. NESG Target HR3443B/SGC-Toronto

PDB ID 2juf

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