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2k1z

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Current revision (19:09, 29 May 2024) (edit) (undo)
 
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==Solution structure of Par-3 PDZ3==
==Solution structure of Par-3 PDZ3==
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<StructureSection load='2k1z' size='340' side='right'caption='[[2k1z]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
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<StructureSection load='2k1z' size='340' side='right'caption='[[2k1z]]' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[2k1z]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2K1Z OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2K1Z FirstGlance]. <br>
<table><tr><td colspan='2'>[[2k1z]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2K1Z OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2K1Z FirstGlance]. <br>
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</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2k20|2k20]]</div></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Pard3, Par3 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Rattus norvegicus])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2k1z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2k1z OCA], [https://pdbe.org/2k1z PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2k1z RCSB], [https://www.ebi.ac.uk/pdbsum/2k1z PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2k1z ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2k1z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2k1z OCA], [https://pdbe.org/2k1z PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2k1z RCSB], [https://www.ebi.ac.uk/pdbsum/2k1z PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2k1z ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/PARD3_RAT PARD3_RAT]] Adapter protein involved in asymmetrical cell division and cell polarization processes. Seems to play a central role in the formation of epithelial tight junctions. Association with PARD6B may prevent the interaction of PARD3 with F11R/JAM1, thereby preventing tight junction assembly. The PARD6-PARD3 complex links GTP-bound Rho small GTPases to atypical protein kinase C proteins. Required for establishment of neuronal polarity and normal axon formation in cultured hippocampal neurons (By similarity). Targets the phosphatase PTEN to cell junctions.<ref>PMID:18082612</ref> <ref>PMID:18550519</ref>
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[https://www.uniprot.org/uniprot/PARD3_RAT PARD3_RAT] Adapter protein involved in asymmetrical cell division and cell polarization processes. Seems to play a central role in the formation of epithelial tight junctions. Association with PARD6B may prevent the interaction of PARD3 with F11R/JAM1, thereby preventing tight junction assembly. The PARD6-PARD3 complex links GTP-bound Rho small GTPases to atypical protein kinase C proteins. Required for establishment of neuronal polarity and normal axon formation in cultured hippocampal neurons (By similarity). Targets the phosphatase PTEN to cell junctions.<ref>PMID:18082612</ref> <ref>PMID:18550519</ref>
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Rattus norvegicus]]
[[Category: Rattus norvegicus]]
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[[Category: Chan, L]]
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[[Category: Chan L]]
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[[Category: Feng, W]]
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[[Category: Feng W]]
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[[Category: Wu, H]]
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[[Category: Wu H]]
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[[Category: Zhang, M]]
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[[Category: Zhang M]]
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[[Category: Alternative splicing]]
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[[Category: Cell cycle]]
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[[Category: Cell division]]
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[[Category: Cell junction]]
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[[Category: Cell polarity]]
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[[Category: Coiled coil]]
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[[Category: Membrane]]
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[[Category: Par-3]]
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[[Category: Pdz domain]]
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[[Category: Phosphoprotein]]
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[[Category: Scaffold protein]]
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[[Category: Signaling protein]]
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[[Category: Tight junction]]
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Current revision

Solution structure of Par-3 PDZ3

PDB ID 2k1z

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