1a7x
From Proteopedia
(New page: 200px<br /> <applet load="1a7x" size="450" color="white" frame="true" align="right" spinBox="true" caption="1a7x, resolution 2.0Å" /> '''FKBP12-FK1012 COMPLE...) |
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| - | [[Image:1a7x.gif|left|200px]]<br /> | + | [[Image:1a7x.gif|left|200px]]<br /><applet load="1a7x" size="350" color="white" frame="true" align="right" spinBox="true" |
| - | <applet load="1a7x" size=" | + | |
caption="1a7x, resolution 2.0Å" /> | caption="1a7x, resolution 2.0Å" /> | ||
'''FKBP12-FK1012 COMPLEX'''<br /> | '''FKBP12-FK1012 COMPLEX'''<br /> | ||
==Overview== | ==Overview== | ||
| - | A ligand that simultaneously binds two proteins must have two high | + | A ligand that simultaneously binds two proteins must have two high affinity protein binding domains joined in a fashion that facilitates, or at least does not prevent, protein-protein interaction. Designing such ligands is challenging, and a high resolution X-ray structure of FKBP12-FK1012A-FKBP12 illustrates the subtleties of one successful design. |
==About this Structure== | ==About this Structure== | ||
| - | 1A7X is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with FKA as [http://en.wikipedia.org/wiki/ligand ligand]. Active as [http://en.wikipedia.org/wiki/Peptidylprolyl_isomerase Peptidylprolyl isomerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.2.1.8 5.2.1.8] Full crystallographic information is available from [http:// | + | 1A7X is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with <scene name='pdbligand=FKA:'>FKA</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Active as [http://en.wikipedia.org/wiki/Peptidylprolyl_isomerase Peptidylprolyl isomerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=5.2.1.8 5.2.1.8] Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1A7X OCA]. |
==Reference== | ==Reference== | ||
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[[Category: Single protein]] | [[Category: Single protein]] | ||
[[Category: Clardy, J.]] | [[Category: Clardy, J.]] | ||
| - | [[Category: Schultz, L | + | [[Category: Schultz, L W.]] |
[[Category: FKA]] | [[Category: FKA]] | ||
[[Category: immunophilin]] | [[Category: immunophilin]] | ||
[[Category: isomerase]] | [[Category: isomerase]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 11:41:50 2008'' |
Revision as of 09:41, 21 February 2008
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FKBP12-FK1012 COMPLEX
Overview
A ligand that simultaneously binds two proteins must have two high affinity protein binding domains joined in a fashion that facilitates, or at least does not prevent, protein-protein interaction. Designing such ligands is challenging, and a high resolution X-ray structure of FKBP12-FK1012A-FKBP12 illustrates the subtleties of one successful design.
About this Structure
1A7X is a Single protein structure of sequence from Homo sapiens with as ligand. Active as Peptidylprolyl isomerase, with EC number 5.2.1.8 Full crystallographic information is available from OCA.
Reference
Chemical inducers of dimerization: the atomic structure of FKBP12-FK1012A-FKBP12., Schultz LW, Clardy J, Bioorg Med Chem Lett. 1998 Jan 6;8(1):1-6. PMID:9871618
Page seeded by OCA on Thu Feb 21 11:41:50 2008
