6s7i
From Proteopedia
(Difference between revisions)
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==Arbitrium receptor from a Bacillus subtilis Katmira33 phage== | ==Arbitrium receptor from a Bacillus subtilis Katmira33 phage== | ||
| - | <StructureSection load='6s7i' size='340' side='right'caption='[[6s7i]]' scene=''> | + | <StructureSection load='6s7i' size='340' side='right'caption='[[6s7i]], [[Resolution|resolution]] 2.40Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6S7I OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6S7I FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[6s7i]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/"vibrio_subtilis"_ehrenberg_1835 "vibrio subtilis" ehrenberg 1835]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6S7I OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6S7I FirstGlance]. <br> |
| - | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6s7i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6s7i OCA], [https://pdbe.org/6s7i PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6s7i RCSB], [https://www.ebi.ac.uk/pdbsum/6s7i PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6s7i ProSAT]</span></td></tr> | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6s7i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6s7i OCA], [https://pdbe.org/6s7i PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6s7i RCSB], [https://www.ebi.ac.uk/pdbsum/6s7i PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6s7i ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | The arbitrium system is employed by phages of the SPbeta family to communicate with their progeny during infection to decide either to follow the lytic or the lysogenic cycle. The system is controlled by a peptide, AimP, that binds to the regulator AimR, inhibiting its DNA-binding activity and expression of aimX. Although the structure of AimR has been elucidated for phages SPbeta and phi3T, there is still controversy regarding the molecular mechanism of AimR function, with two different proposed models for SPbeta. In this study, we deepen our understanding of the system by solving the structure of an additional AimR that shows chimerical characteristics with the SPbeta receptor. The crystal structures of this AimR (apo, AimP-bound and DNA-bound) together with in vitro and in vivo analyses confirm a mechanism of action by AimP-induced conformational restriction, shedding light on peptide specificity and cross regulation with relevant biological implications. | ||
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| + | Insights into the mechanism of action of the arbitrium communication system in SPbeta phages.,Gallego Del Sol F, Quiles-Puchalt N, Brady A, Penades JR, Marina A Nat Commun. 2022 Jun 24;13(1):3627. doi: 10.1038/s41467-022-31144-3. PMID:35750663<ref>PMID:35750663</ref> | ||
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| + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
| + | </div> | ||
| + | <div class="pdbe-citations 6s7i" style="background-color:#fffaf0;"></div> | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| + | [[Category: Vibrio subtilis ehrenberg 1835]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: | + | [[Category: Marina, A]] |
| - | [[Category: | + | [[Category: Sol, F Gallego del]] |
| + | [[Category: Arbitrium]] | ||
| + | [[Category: Dna binding protein]] | ||
Revision as of 16:17, 6 July 2022
Arbitrium receptor from a Bacillus subtilis Katmira33 phage
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