This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
6wfv
From Proteopedia
(Difference between revisions)
| Line 1: | Line 1: | ||
==The crystal structure of a collagen galactosylhydroxylysyl glucosyltransferase from human== | ==The crystal structure of a collagen galactosylhydroxylysyl glucosyltransferase from human== | ||
| - | <StructureSection load='6wfv' size='340' side='right'caption='[[6wfv]]' scene=''> | + | <StructureSection load='6wfv' size='340' side='right'caption='[[6wfv]], [[Resolution|resolution]] 1.70Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6WFV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6WFV FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[6wfv]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6WFV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6WFV FirstGlance]. <br> |
| - | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6wfv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6wfv OCA], [https://pdbe.org/6wfv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6wfv RCSB], [https://www.ebi.ac.uk/pdbsum/6wfv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6wfv ProSAT]</span></td></tr> | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=TRS:2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>TRS</scene>, <scene name='pdbligand=UDP:URIDINE-5-DIPHOSPHATE'>UDP</scene></td></tr> |
| + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">PLOD3 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6wfv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6wfv OCA], [https://pdbe.org/6wfv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6wfv RCSB], [https://www.ebi.ac.uk/pdbsum/6wfv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6wfv ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | == Disease == | ||
| + | [[https://www.uniprot.org/uniprot/PLOD3_HUMAN PLOD3_HUMAN]] Connective tissue disorder due to lysyl hydroxylase-3 deficiency. The disease is caused by mutations affecting the gene represented in this entry. | ||
| + | == Function == | ||
| + | [[https://www.uniprot.org/uniprot/PLOD3_HUMAN PLOD3_HUMAN]] Forms hydroxylysine residues in -Xaa-Lys-Gly- sequences in collagens. These hydroxylysines serve as sites of attachment for carbohydrate units and are essential for the stability of the intermolecular collagen cross-links.[UniProtKB:P24802] | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| + | [[Category: Human]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: Guo H | + | [[Category: Guo, H F]] |
| - | [[Category: Kurie | + | [[Category: Kurie, J M]] |
| - | [[Category: Miller | + | [[Category: Miller, M D]] |
| - | [[Category: | + | [[Category: Phillips, G N]] |
| - | [[Category: Tainer | + | [[Category: Tainer, J A]] |
| - | [[Category: Tsai C | + | [[Category: Tsai, C L]] |
| + | [[Category: Magnesium]] | ||
| + | [[Category: Manganese]] | ||
| + | [[Category: Rossmann fold]] | ||
| + | [[Category: Transferase]] | ||
| + | [[Category: Udp]] | ||
Revision as of 09:33, 15 September 2021
The crystal structure of a collagen galactosylhydroxylysyl glucosyltransferase from human
| |||||||||||
Categories: Human | Large Structures | Guo, H F | Kurie, J M | Miller, M D | Phillips, G N | Tainer, J A | Tsai, C L | Magnesium | Manganese | Rossmann fold | Transferase | Udp
