6yia

==14-3-3 sigma in complex with SMAD2 pS465 peptide==

<StructureSection load='6yia' size='340' side='right'caption='[[6yia]], [[Resolution|resolution]] 1.30&Aring;' scene=''>

<table><tr><td colspan='2'>[[6yia]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6YIA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6YIA FirstGlance]. <br>

</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.3&#8491;</td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6yia FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6yia OCA], [https://pdbe.org/6yia PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6yia RCSB], [https://www.ebi.ac.uk/pdbsum/6yia PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6yia ProSAT]</span></td></tr>

== Function ==

[https://www.uniprot.org/uniprot/1433S_HUMAN 1433S_HUMAN] Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. When bound to KRT17, regulates protein synthesis and epithelial cell growth by stimulating Akt/mTOR pathway (By similarity). p53-regulated inhibitor of G2/M progression.

[[Category: Homo sapiens]]

[[Category: Graf S]]

[[Category: Kiehstaller S]]