6ym4
From Proteopedia
(Difference between revisions)
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==Crystal structure of BAY-297 with PIP4K2A== | ==Crystal structure of BAY-297 with PIP4K2A== | ||
| - | <StructureSection load='6ym4' size='340' side='right'caption='[[6ym4]]' scene=''> | + | <StructureSection load='6ym4' size='340' side='right'caption='[[6ym4]], [[Resolution|resolution]] 1.95Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6YM4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6YM4 FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[6ym4]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6YM4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6YM4 FirstGlance]. <br> |
| - | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6ym4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ym4 OCA], [https://pdbe.org/6ym4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6ym4 RCSB], [https://www.ebi.ac.uk/pdbsum/6ym4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6ym4 ProSAT]</span></td></tr> | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=P4Z:(2~{R})-2-[[2-[4-(3-chloranyl-2-fluoranyl-phenyl)phenyl]-3-cyano-1,7-naphthyridin-4-yl]amino]butanamide'>P4Z</scene></td></tr> |
| + | <tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=PHD:ASPARTYL+PHOSPHATE'>PHD</scene></td></tr> | ||
| + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">PIP4K2A, PIP5K2, PIP5K2A ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr> | ||
| + | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/1-phosphatidylinositol-5-phosphate_4-kinase 1-phosphatidylinositol-5-phosphate 4-kinase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.149 2.7.1.149] </span></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6ym4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ym4 OCA], [https://pdbe.org/6ym4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6ym4 RCSB], [https://www.ebi.ac.uk/pdbsum/6ym4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6ym4 ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | == Disease == | ||
| + | [[https://www.uniprot.org/uniprot/PI42A_HUMAN PI42A_HUMAN]] Precursor B-cell acute lymphoblastic leukemia. | ||
| + | == Function == | ||
| + | [[https://www.uniprot.org/uniprot/PI42A_HUMAN PI42A_HUMAN]] Catalyzes the phosphorylation of phosphatidylinositol 5-phosphate (PtdIns5P) on the fourth hydroxyl of the myo-inositol ring, to form phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2). May exert its function by regulating the levels of PtdIns5P, which functions in the cytosol by increasing AKT activity and in the nucleus signals through ING2. May regulate the pool of cytosolic PtdIns5P in response to the activation of tyrosine phosphorylation. May negatively regulate insulin-stimulated glucose uptake by lowering the levels of PtdIns5P. May be involved in thrombopoiesis, and the terminal maturation of megakaryocytes and regulation of their size.<ref>PMID:18364242</ref> | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| + | [[Category: 1-phosphatidylinositol-5-phosphate 4-kinase]] | ||
| + | [[Category: Human]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: Bauser M]] | + | [[Category: Bauser, M]] |
| - | [[Category: Braeuer N]] | + | [[Category: Braeuer, N]] |
| - | [[Category: Christ C]] | + | [[Category: Christ, C]] |
| - | [[Category: Haegebarth A]] | + | [[Category: Haegebarth, A]] |
| - | [[Category: Holton | + | [[Category: Holton, S J]] |
| - | [[Category: Irlbacher H]] | + | [[Category: Irlbacher, H]] |
| - | [[Category: Lechner C]] | + | [[Category: Laak, T ter]] |
| - | [[Category: Lemos C]] | + | [[Category: Lechner, C]] |
| - | [[Category: Lesche R]] | + | [[Category: Lemos, C]] |
| - | [[Category: Lienau P]] | + | [[Category: Lesche, R]] |
| - | [[Category: Meier R]] | + | [[Category: Lienau, P]] |
| - | [[Category: Mumberg D]] | + | [[Category: Meier, R]] |
| - | [[Category: Nicke B]] | + | [[Category: Mumberg, D]] |
| - | [[Category: Puetter V]] | + | [[Category: Nicke, B]] |
| - | [[Category: Weiske J]] | + | [[Category: Nussbaum, F von]] |
| - | [[Category: Wortmann L]] | + | [[Category: Puetter, V]] |
| - | [[Category: | + | [[Category: Weiske, J]] |
| - | [[Category: | + | [[Category: Wortmann, L]] |
| + | [[Category: Pip4k2a]] | ||
| + | [[Category: Transferase]] | ||
Revision as of 09:01, 5 May 2021
Crystal structure of BAY-297 with PIP4K2A
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Categories: 1-phosphatidylinositol-5-phosphate 4-kinase | Human | Large Structures | Bauser, M | Braeuer, N | Christ, C | Haegebarth, A | Holton, S J | Irlbacher, H | Laak, T ter | Lechner, C | Lemos, C | Lesche, R | Lienau, P | Meier, R | Mumberg, D | Nicke, B | Nussbaum, F von | Puetter, V | Weiske, J | Wortmann, L | Pip4k2a | Transferase
