6ye9
From Proteopedia
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<StructureSection load='6ye9' size='340' side='right'caption='[[6ye9]], [[Resolution|resolution]] 1.80Å' scene=''> | <StructureSection load='6ye9' size='340' side='right'caption='[[6ye9]], [[Resolution|resolution]] 1.80Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[6ye9]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/ | + | <table><tr><td colspan='2'>[[6ye9]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6YE9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6YE9 FirstGlance]. <br> |
| - | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=OO8:[2-[2-oxidanylidene-2-[(phenylmethyl)amino]ethoxy]phenyl]phosphonic+acid'>OO8</scene> | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8Å</td></tr> |
| - | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=OO8:[2-[2-oxidanylidene-2-[(phenylmethyl)amino]ethoxy]phenyl]phosphonic+acid'>OO8</scene></td></tr> | |
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6ye9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ye9 OCA], [https://pdbe.org/6ye9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6ye9 RCSB], [https://www.ebi.ac.uk/pdbsum/6ye9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6ye9 ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6ye9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6ye9 OCA], [https://pdbe.org/6ye9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6ye9 RCSB], [https://www.ebi.ac.uk/pdbsum/6ye9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6ye9 ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
| - | + | [https://www.uniprot.org/uniprot/1433S_HUMAN 1433S_HUMAN] Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. When bound to KRT17, regulates protein synthesis and epithelial cell growth by stimulating Akt/mTOR pathway (By similarity). p53-regulated inhibitor of G2/M progression. | |
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: | + | [[Category: Homo sapiens]] |
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: Ottmann | + | [[Category: Ottmann C]] |
| - | [[Category: Visser | + | [[Category: Visser EJ]] |
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Current revision
Small-molecule inhibitor of 14-3-3 protein-protein interactions
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