2khb

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==Solution structure of linear kalata B1 (loop 6)==
==Solution structure of linear kalata B1 (loop 6)==
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<StructureSection load='2khb' size='340' side='right'caption='[[2khb]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
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<StructureSection load='2khb' size='340' side='right'caption='[[2khb]]' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2khb]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Hedyotis_affinis Hedyotis affinis]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KHB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2KHB FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2khb]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Oldenlandia_affinis Oldenlandia affinis]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KHB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2KHB FirstGlance]. <br>
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</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1nb1|1nb1]]</div></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">OAK1 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=60225 Hedyotis affinis])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2khb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2khb OCA], [https://pdbe.org/2khb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2khb RCSB], [https://www.ebi.ac.uk/pdbsum/2khb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2khb ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2khb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2khb OCA], [https://pdbe.org/2khb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2khb RCSB], [https://www.ebi.ac.uk/pdbsum/2khb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2khb ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/KAB1_OLDAF KAB1_OLDAF]] Probably participates in a plant defense mechanism. Has antibiotic activity. Has a diuretic effect. Has a uterotonic effect in humans. Active against the Gram-positive S.aureus with a minimum inhibition concentration of approximately 0.2 microM. Relatively ineffective against Gram-negative bacteria such as E.coli and P.aeruginosa. Inhibitory effect on the growth and development of larvae from H.punctigera. The unmodified form has hemolytic activity, the oxidized form lacks hemolytic activity. If the protein is linearized, hemolytic activity is lost.<ref>PMID:17534989</ref> <ref>PMID:12779323</ref>
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[https://www.uniprot.org/uniprot/KAB1_OLDAF KAB1_OLDAF] Probably participates in a plant defense mechanism. Has antibiotic activity. Has a diuretic effect. Has a uterotonic effect in humans. Active against the Gram-positive S.aureus with a minimum inhibition concentration of approximately 0.2 microM. Relatively ineffective against Gram-negative bacteria such as E.coli and P.aeruginosa. Inhibitory effect on the growth and development of larvae from H.punctigera. The unmodified form has hemolytic activity, the oxidized form lacks hemolytic activity. If the protein is linearized, hemolytic activity is lost.<ref>PMID:17534989</ref> <ref>PMID:12779323</ref>
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Hedyotis affinis]]
 
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Craik, D J]]
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[[Category: Oldenlandia affinis]]
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[[Category: Wang, C K]]
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[[Category: Craik DJ]]
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[[Category: Antimicrobial protein]]
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[[Category: Wang CK]]
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[[Category: Cyclotide]]
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[[Category: Cytolysis]]
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[[Category: Disulfide bond]]
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[[Category: Hemolysis]]
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[[Category: Knottin]]
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[[Category: Oxidation]]
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[[Category: Pharmaceutical]]
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[[Category: Plant defense]]
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Revision as of 12:51, 20 December 2023

Solution structure of linear kalata B1 (loop 6)

PDB ID 2khb

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