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| | ==Mesencephalic astrocyte-derived neurotrophic factor (MANF)== | | ==Mesencephalic astrocyte-derived neurotrophic factor (MANF)== |
| - | <StructureSection load='2kvd' size='340' side='right'caption='[[2kvd]], [[NMR_Ensembles_of_Models | 15 NMR models]]' scene=''> | + | <StructureSection load='2kvd' size='340' side='right'caption='[[2kvd]]' scene=''> |
| | == Structural highlights == | | == Structural highlights == |
| - | <table><tr><td colspan='2'>[[2kvd]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KVD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2KVD FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[2kvd]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KVD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2KVD FirstGlance]. <br> |
| - | </td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2kve|2kve]]</div></td></tr> | + | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2kvd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kvd OCA], [https://pdbe.org/2kvd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2kvd RCSB], [https://www.ebi.ac.uk/pdbsum/2kvd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2kvd ProSAT]</span></td></tr> |
| - | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">mesencephalic astrocyte-derived neurotrophic factor ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
| + | |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2kvd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kvd OCA], [https://pdbe.org/2kvd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2kvd RCSB], [https://www.ebi.ac.uk/pdbsum/2kvd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2kvd ProSAT]</span></td></tr> | + | |
| | </table> | | </table> |
| | == Disease == | | == Disease == |
| - | [[https://www.uniprot.org/uniprot/MANF_HUMAN MANF_HUMAN]] Familial pancreatic carcinoma.
| + | [https://www.uniprot.org/uniprot/MANF_HUMAN MANF_HUMAN] Familial pancreatic carcinoma. |
| | == Function == | | == Function == |
| - | [[https://www.uniprot.org/uniprot/MANF_HUMAN MANF_HUMAN]] Selectively promotes the survival of dopaminergic neurons of the ventral mid-brain. Modulates GABAergic transmission to the dopaminergic neurons of the substantia nigra. Enhances spontaneous, as well as evoked, GABAergic inhibitory postsynaptic currents in dopaminergic neurons (By similarity). Inhibits cell proliferation and endoplasmic reticulum (ER) stress-induced cell death.<ref>PMID:12794311</ref> <ref>PMID:18561914</ref>
| + | [https://www.uniprot.org/uniprot/MANF_HUMAN MANF_HUMAN] Selectively promotes the survival of dopaminergic neurons of the ventral mid-brain. Modulates GABAergic transmission to the dopaminergic neurons of the substantia nigra. Enhances spontaneous, as well as evoked, GABAergic inhibitory postsynaptic currents in dopaminergic neurons (By similarity). Inhibits cell proliferation and endoplasmic reticulum (ER) stress-induced cell death.<ref>PMID:12794311</ref> <ref>PMID:18561914</ref> |
| | <div style="background-color:#fffaf0;"> | | <div style="background-color:#fffaf0;"> |
| | == Publication Abstract from PubMed == | | == Publication Abstract from PubMed == |
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| | __TOC__ | | __TOC__ |
| | </StructureSection> | | </StructureSection> |
| - | [[Category: Human]] | + | [[Category: Homo sapiens]] |
| | [[Category: Large Structures]] | | [[Category: Large Structures]] |
| - | [[Category: Hellman, M H]] | + | [[Category: Hellman MH]] |
| - | [[Category: Peranen, J]] | + | [[Category: Peranen J]] |
| - | [[Category: Permi, P]] | + | [[Category: Permi P]] |
| - | [[Category: Saarma, M]] | + | [[Category: Saarma M]] |
| - | [[Category: Disulfide bond]]
| + | |
| - | [[Category: Glycoprotein]]
| + | |
| - | [[Category: Growth factor]]
| + | |
| - | [[Category: Hormone]]
| + | |
| - | [[Category: Secreted]]
| + | |
| - | [[Category: Sialic acid]]
| + | |
| - | [[Category: Unfolded protein response]]
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| Structural highlights
Disease
MANF_HUMAN Familial pancreatic carcinoma.
Function
MANF_HUMAN Selectively promotes the survival of dopaminergic neurons of the ventral mid-brain. Modulates GABAergic transmission to the dopaminergic neurons of the substantia nigra. Enhances spontaneous, as well as evoked, GABAergic inhibitory postsynaptic currents in dopaminergic neurons (By similarity). Inhibits cell proliferation and endoplasmic reticulum (ER) stress-induced cell death.[1] [2]
Publication Abstract from PubMed
Mesencephalic astrocyte-derived neurotrophic factor (MANF) protects neurons and repairs the Parkinson's disease-like symptoms in a rat 6-hydroxydopamine model. We show a three-dimensional solution structure of human MANF that differs drastically from other neurotrophic factors. Remarkably, the C-terminal domain of MANF (C-MANF) is homologous to the SAP domain of Ku70, a well-known inhibitor of pro-apoptotic Bcl-2-associated X protein (Bax). Cellular studies confirm that MANF and C-MANF protect neurons intracellularly as efficiently as Ku70.
Neurotrophic factor MANF has a unique mechanism to rescue apoptotic neurons.,Hellman M, Arumae U, Yu LY, Lindholm P, Peranen J, Saarma M, Permi P J Biol Chem. 2010 Nov 3. PMID:21047780[3]
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.
References
- ↑ Petrova P, Raibekas A, Pevsner J, Vigo N, Anafi M, Moore MK, Peaire AE, Shridhar V, Smith DI, Kelly J, Durocher Y, Commissiong JW. MANF: a new mesencephalic, astrocyte-derived neurotrophic factor with selectivity for dopaminergic neurons. J Mol Neurosci. 2003 Apr;20(2):173-88. PMID:12794311
- ↑ Apostolou A, Shen Y, Liang Y, Luo J, Fang S. Armet, a UPR-upregulated protein, inhibits cell proliferation and ER stress-induced cell death. Exp Cell Res. 2008 Aug 1;314(13):2454-67. doi: 10.1016/j.yexcr.2008.05.001. Epub , 2008 May 13. PMID:18561914 doi:http://dx.doi.org/10.1016/j.yexcr.2008.05.001
- ↑ Hellman M, Arumae U, Yu LY, Lindholm P, Peranen J, Saarma M, Permi P. Neurotrophic factor MANF has a unique mechanism to rescue apoptotic neurons. J Biol Chem. 2010 Nov 3. PMID:21047780 doi:10.1074/jbc.M110.146738
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