2kwl
From Proteopedia
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==Solution Structure of acyl carrier protein from Borrelia burgdorferi== | ==Solution Structure of acyl carrier protein from Borrelia burgdorferi== | ||
| - | <StructureSection load='2kwl' size='340' side='right'caption='[[2kwl | + | <StructureSection load='2kwl' size='340' side='right'caption='[[2kwl]]' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[2kwl]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/ | + | <table><tr><td colspan='2'>[[2kwl]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Borreliella_burgdorferi Borreliella burgdorferi]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KWL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2KWL FirstGlance]. <br> |
| - | </td></tr><tr id=' | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> |
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2kwl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kwl OCA], [https://pdbe.org/2kwl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2kwl RCSB], [https://www.ebi.ac.uk/pdbsum/2kwl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2kwl ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2kwl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kwl OCA], [https://pdbe.org/2kwl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2kwl RCSB], [https://www.ebi.ac.uk/pdbsum/2kwl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2kwl ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
| - | + | [https://www.uniprot.org/uniprot/ACP_BORBU ACP_BORBU] Carrier of the growing fatty acid chain in fatty acid biosynthesis (By similarity). | |
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2kwl ConSurf]. | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2kwl ConSurf]. | ||
<div style="clear:both"></div> | <div style="clear:both"></div> | ||
| - | <div style="background-color:#fffaf0;"> | ||
| - | == Publication Abstract from PubMed == | ||
| - | Nearly complete resonance assignment and the high-resolution NMR structure of the acyl-carrier protein from Borrelia burgdorferi, a target of the Seattle Structural Genomics Center for Infectious Disease (SSGCID) structure-determination pipeline, are reported. This protein was chosen as a potential target for drug-discovery efforts because of its involvement in fatty-acid biosynthesis, an essential metabolic pathway, in bacteria. It was possible to assign >98% of backbone resonances and >92% of side-chain resonances using multidimensional NMR spectroscopy. The NMR structure was determined to a backbone r.m.s.d. of 0.4 A and contained four alpha-helices and two 3(10)-helices. A structure-homology search revealed that this protein is highly similar to the acyl-carrier protein from Aquifex aeolicus. | ||
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| - | NMR structure of an acyl-carrier protein from Borrelia burgdorferi.,Barnwal RP, Van Voorhis WC, Varani G Acta Crystallogr Sect F Struct Biol Cryst Commun. 2011 Sep 1;67(Pt, 9):1137-40. Epub 2011 Aug 13. PMID:21904063<ref>PMID:21904063</ref> | ||
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| - | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
| - | </div> | ||
| - | <div class="pdbe-citations 2kwl" style="background-color:#fffaf0;"></div> | ||
==See Also== | ==See Also== | ||
*[[Acyl carrier protein 3D structures|Acyl carrier protein 3D structures]] | *[[Acyl carrier protein 3D structures|Acyl carrier protein 3D structures]] | ||
| - | == References == | ||
| - | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: | + | [[Category: Borreliella burgdorferi]] |
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: Barnwal | + | [[Category: Barnwal R]] |
| - | [[Category: Moody | + | [[Category: Moody J]] |
| - | + | [[Category: Varani G]] | |
| - | [[Category: Varani | + | [[Category: Vittal V]] |
| - | [[Category: Vittal | + | |
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Current revision
Solution Structure of acyl carrier protein from Borrelia burgdorferi
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