2l00
From Proteopedia
(Difference between revisions)
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==Solution structure of the non-covalent complex of the ZNF216 A20 domain with ubiquitin== | ==Solution structure of the non-covalent complex of the ZNF216 A20 domain with ubiquitin== | ||
| - | <StructureSection load='2l00' size='340' side='right'caption='[[2l00 | + | <StructureSection load='2l00' size='340' side='right'caption='[[2l00]]' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[2l00]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/ | + | <table><tr><td colspan='2'>[[2l00]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus] and [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2L00 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2L00 FirstGlance]. <br> |
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | ||
| - | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2kzy|2kzy]]</div></td></tr> | ||
| - | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">rCG_48158, Zfand5, Zfp216_predicted ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Buffalo rat]), PUBI-2, UBI1 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 ATCC 18824])</td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2l00 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2l00 OCA], [https://pdbe.org/2l00 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2l00 RCSB], [https://www.ebi.ac.uk/pdbsum/2l00 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2l00 ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2l00 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2l00 OCA], [https://pdbe.org/2l00 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2l00 RCSB], [https://www.ebi.ac.uk/pdbsum/2l00 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2l00 ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
| - | + | [https://www.uniprot.org/uniprot/ZFAN5_RAT ZFAN5_RAT] Involved in protein degradation via the ubiquitin-proteasome system. May act by anchoring ubiquitinated proteins to the proteasome. Plays a role in ubiquitin-mediated protein degradation during muscle atrophy. Plays a role in the regulation of NF-kappa-B activation and apoptosis. Inhibits NF-kappa-B activation triggered by overexpression of RIPK1 and TRAF6 but not of RELA. Inhibits also tumor necrosis factor (TNF), IL-1 and TLR4-induced NF-kappa-B activation in a dose-dependent manner. Overexpression sensitizes cells to TNF-induced apoptosis. Is a potent inhibitory factor for osteoclast differentiation (By similarity). | |
==See Also== | ==See Also== | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: Atcc 18824]] | ||
| - | [[Category: Buffalo rat]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: | + | [[Category: Rattus norvegicus]] |
| - | [[Category: | + | [[Category: Saccharomyces cerevisiae]] |
| - | [[Category: | + | [[Category: Garner TP]] |
| - | [[Category: | + | [[Category: Layfield R]] |
| - | [[Category: | + | [[Category: Long JE]] |
| - | [[Category: | + | [[Category: Searle MS]] |
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Revision as of 08:10, 18 January 2023
Solution structure of the non-covalent complex of the ZNF216 A20 domain with ubiquitin
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