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2l1u

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Current revision (06:51, 1 May 2024) (edit) (undo)
 
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==Structure-Functional Analysis of Mammalian MsrB2 protein==
==Structure-Functional Analysis of Mammalian MsrB2 protein==
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<StructureSection load='2l1u' size='340' side='right'caption='[[2l1u]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
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<StructureSection load='2l1u' size='340' side='right'caption='[[2l1u]]' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2l1u]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2L1U OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2L1U FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2l1u]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2L1U OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2L1U FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Msrb2 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2l1u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2l1u OCA], [https://pdbe.org/2l1u PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2l1u RCSB], [https://www.ebi.ac.uk/pdbsum/2l1u PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2l1u ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2l1u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2l1u OCA], [https://pdbe.org/2l1u PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2l1u RCSB], [https://www.ebi.ac.uk/pdbsum/2l1u PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2l1u ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/MSRB2_MOUSE MSRB2_MOUSE]] Methionine-sulfoxide reductase that specifically reduces methionine (R)-sulfoxide back to methionine. While in many cases, methionine oxidation is the result of random oxidation following oxidative stress, methionine oxidation is also a post-translational modification that takes place on specific residue. Upon oxidative stress, may play a role in the preservation of mitochondrial integrity by decreasing the intracellular reactive oxygen species build-up through its scavenging role, hence contributing to cell survival and protein maintenance.<ref>PMID:14699060</ref> <ref>PMID:23911929</ref>
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[https://www.uniprot.org/uniprot/MSRB2_MOUSE MSRB2_MOUSE] Methionine-sulfoxide reductase that specifically reduces methionine (R)-sulfoxide back to methionine. While in many cases, methionine oxidation is the result of random oxidation following oxidative stress, methionine oxidation is also a post-translational modification that takes place on specific residue. Upon oxidative stress, may play a role in the preservation of mitochondrial integrity by decreasing the intracellular reactive oxygen species build-up through its scavenging role, hence contributing to cell survival and protein maintenance.<ref>PMID:14699060</ref> <ref>PMID:23911929</ref>
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Lk3 transgenic mice]]
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[[Category: Mus musculus]]
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[[Category: Aachmann, F L]]
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[[Category: Aachmann FL]]
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[[Category: Conte, R Del]]
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[[Category: Del Conte R]]
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[[Category: Dikiy, A]]
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[[Category: Dikiy A]]
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[[Category: Gladyshev, V N]]
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[[Category: Gladyshev VN]]
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[[Category: Kim, H]]
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[[Category: Kim H]]
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[[Category: Kwak, G]]
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[[Category: Kwak G]]
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[[Category: Methionine sulfoxide reductase]]
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[[Category: Msrb]]
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[[Category: Oxidoreductase]]
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Current revision

Structure-Functional Analysis of Mammalian MsrB2 protein

PDB ID 2l1u

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