2l1x

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==The Solution Structure Of Human Parathyroid Hormone-Related Protein==
==The Solution Structure Of Human Parathyroid Hormone-Related Protein==
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<StructureSection load='2l1x' size='340' side='right'caption='[[2l1x]], [[NMR_Ensembles_of_Models | 10 NMR models]]' scene=''>
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<StructureSection load='2l1x' size='340' side='right'caption='[[2l1x]]' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2l1x]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2L1X OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2L1X FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2l1x]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2L1X OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2L1X FirstGlance]. <br>
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</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">PTH ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2l1x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2l1x OCA], [https://pdbe.org/2l1x PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2l1x RCSB], [https://www.ebi.ac.uk/pdbsum/2l1x PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2l1x ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2l1x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2l1x OCA], [https://pdbe.org/2l1x PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2l1x RCSB], [https://www.ebi.ac.uk/pdbsum/2l1x PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2l1x ProSAT]</span></td></tr>
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</table>
</table>
== Disease ==
== Disease ==
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[[https://www.uniprot.org/uniprot/PTHY_HUMAN PTHY_HUMAN]] Defects in PTH are a cause of familial isolated hypoparathyroidism (FIH) [MIM:[https://omim.org/entry/146200 146200]]; also called autosomal dominant hypoparathyroidism or autosomal dominant hypocalcemia. FIH is characterized by hypocalcemia and hyperphosphatemia due to inadequate secretion of parathyroid hormone. Symptoms are seizures, tetany and cramps. FIH exist both as autosomal dominant and recessive forms of hypoparathyroidism.<ref>PMID:2212001</ref> <ref>PMID:10523031</ref> <ref>PMID:18056632</ref>
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[https://www.uniprot.org/uniprot/PTHY_HUMAN PTHY_HUMAN] Defects in PTH are a cause of familial isolated hypoparathyroidism (FIH) [MIM:[https://omim.org/entry/146200 146200]; also called autosomal dominant hypoparathyroidism or autosomal dominant hypocalcemia. FIH is characterized by hypocalcemia and hyperphosphatemia due to inadequate secretion of parathyroid hormone. Symptoms are seizures, tetany and cramps. FIH exist both as autosomal dominant and recessive forms of hypoparathyroidism.<ref>PMID:2212001</ref> <ref>PMID:10523031</ref> <ref>PMID:18056632</ref>
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/PTHY_HUMAN PTHY_HUMAN]] PTH elevates calcium level by dissolving the salts in bone and preventing their renal excretion. Stimulates [1-14C]-2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblastic cells.<ref>PMID:21076856</ref>
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[https://www.uniprot.org/uniprot/PTHY_HUMAN PTHY_HUMAN] PTH elevates calcium level by dissolving the salts in bone and preventing their renal excretion. Stimulates [1-14C]-2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblastic cells.<ref>PMID:21076856</ref>
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Lin, D]]
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[[Category: Lin D]]
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[[Category: Lin, K]]
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[[Category: Lin K]]
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[[Category: Liu, J]]
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[[Category: Liu J]]
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[[Category: You, Q]]
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[[Category: You Q]]
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[[Category: Hormone]]
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[[Category: Pthrp]]
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Revision as of 08:13, 18 January 2023

The Solution Structure Of Human Parathyroid Hormone-Related Protein

PDB ID 2l1x

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