2l7h

From Proteopedia

(Difference between revisions)

Revision as of 08:24, 18 January 2023

The solution structure of the HAMP domain of the hypothetical transmembrane receptor Af1503

Structural highlights

2l7h is a 2 chain structure with sequence from Archaeoglobus fulgidus. This structure supersedes the now removed PDB entries 2asw and 2asx. Full experimental information is available from OCA. For a guided tour on the structure components use FirstGlance.
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

O28769_ARCFU

Publication Abstract from PubMed

HAMP domains mediate signal transduction in over 7500 enzyme-coupled receptors represented in all kingdoms of life. The HAMP domain of the putative archaeal receptor Af1503 has a parallel, dimeric, four-helical coiled coil structure, but with unusual core packing, related to canonical packing by concerted axial rotation of the helices. This has led to the gearbox model for signal transduction, whereby the alternate packing modes correspond to signaling states. Here we present structures of a series of Af1503 HAMP variants. We show that substitution of a conserved small side chain within the domain core (A291) for larger residues induces a gradual transition in packing mode, involving both changes in helix rotation and bundle shape, which are most prominent at the C-terminal, output end of the domain. These are correlated with activity and ligand response in vitro and in vivo by incorporating Af1503 HAMP into mycobacterial adenylyl cyclase assay systems.

The Mechanisms of HAMP-Mediated Signaling in Transmembrane Receptors.,Ferris HU, Dunin-Horkawicz S, Mondejar LG, Hulko M, Hantke K, Martin J, Schultz JE, Zeth K, Lupas AN, Coles M Structure. 2011 Mar 9;19(3):378-85. PMID:21397188^[1]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

References

↑ Ferris HU, Dunin-Horkawicz S, Mondejar LG, Hulko M, Hantke K, Martin J, Schultz JE, Zeth K, Lupas AN, Coles M. The Mechanisms of HAMP-Mediated Signaling in Transmembrane Receptors. Structure. 2011 Mar 9;19(3):378-85. PMID:21397188 doi:10.1016/j.str.2011.01.006

1 Structural highlights
2 Function
3 Publication Abstract from PubMed
4 References

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2l7h"

@@ Line 1: / Line 1: @@
 ==The solution structure of the HAMP domain of the hypothetical transmembrane receptor Af1503==
-<StructureSection load='2l7h' size='340' side='right'caption='[[2l7h]], [[NMR_Ensembles_of_Models | 18 NMR models]]' scene=''>
+<StructureSection load='2l7h' size='340' side='right'caption='[[2l7h]]' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[2l7h]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Arcfl Arcfl]. This structure supersedes the now removed PDB entries [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=2asw 2asw] and [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=2asx 2asx]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2L7H OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2L7H FirstGlance]. <br>
+<table><tr><td colspan='2'>[[2l7h]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Archaeoglobus_fulgidus Archaeoglobus fulgidus]. This structure supersedes the now removed PDB entries [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=2asw 2asw] and [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=2asx 2asx]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2L7H OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2L7H FirstGlance]. <br>
-</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2asw|2asw]], [[2l7i|2l7i]], [[2y0q|2y0q]], [[2y0t|2y0t]], [[2y20|2y20]], [[2y21|2y21]]</div></td></tr>
+</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2l7h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2l7h OCA], [https://pdbe.org/2l7h PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2l7h RCSB], [https://www.ebi.ac.uk/pdbsum/2l7h PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2l7h ProSAT]</span></td></tr>
-<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">af1503, AF_1503 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=2234 ARCFL])</td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2l7h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2l7h OCA], [https://pdbe.org/2l7h PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2l7h RCSB], [https://www.ebi.ac.uk/pdbsum/2l7h PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2l7h ProSAT]</span></td></tr>
 </table>
+== Function ==
+[https://www.uniprot.org/uniprot/O28769_ARCFU O28769_ARCFU]
 <div style="background-color:#fffaf0;">
 == Publication Abstract from PubMed ==
@@ Line 21: / Line 21: @@
 __TOC__
 </StructureSection>
-[[Category: Arcfl]]
+[[Category: Archaeoglobus fulgidus]]
 [[Category: Large Structures]]
-[[Category: Coles, M]]
+[[Category: Coles M]]
-[[Category: Hulko, M]]
+[[Category: Hulko M]]
-[[Category: Lupas, A N]]
+[[Category: Lupas AN]]
-[[Category: Martin, J]]
+[[Category: Martin J]]
-[[Category: Complementary x-da]]
-[[Category: Signaling protein]]

2l7h

From Proteopedia

Revision as of 08:24, 18 January 2023

The solution structure of the HAMP domain of the hypothetical transmembrane receptor Af1503

Structural highlights

Function

Publication Abstract from PubMed

References

Contents

Proteopedia Page Contributors and Editors (what is this?)

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