2l7m
From Proteopedia
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==Solution Structure of the Pitx2 Homeodomain R24H mutant== | ==Solution Structure of the Pitx2 Homeodomain R24H mutant== | ||
| - | <StructureSection load='2l7m' size='340' side='right'caption='[[2l7m | + | <StructureSection load='2l7m' size='340' side='right'caption='[[2l7m]]' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[2l7m]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/ | + | <table><tr><td colspan='2'>[[2l7m]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2L7M OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2L7M FirstGlance]. <br> |
| - | </td></tr> | + | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2l7m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2l7m OCA], [https://pdbe.org/2l7m PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2l7m RCSB], [https://www.ebi.ac.uk/pdbsum/2l7m PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2l7m ProSAT]</span></td></tr> |
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| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2l7m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2l7m OCA], [https://pdbe.org/2l7m PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2l7m RCSB], [https://www.ebi.ac.uk/pdbsum/2l7m PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2l7m ProSAT]</span></td></tr> | + | |
</table> | </table> | ||
== Disease == | == Disease == | ||
| - | + | [https://www.uniprot.org/uniprot/PITX2_HUMAN PITX2_HUMAN] Peters anomaly;Axenfeld anomaly;Rieger anomaly;Ring dermoid of cornea;Axenfeld-Rieger syndrome. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry. | |
== Function == | == Function == | ||
| - | + | [https://www.uniprot.org/uniprot/PITX2_HUMAN PITX2_HUMAN] Controls cell proliferation in a tissue-specific manner and is involved in morphogenesis. During embryonic development, exerts a role in the expansion of muscle progenitors. May play a role in the proper localization of asymmetric organs such as the heart and stomach. Isoform PTX2C is involved in left-right asymmetry the developing embryo (By similarity). | |
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: | + | [[Category: Homo sapiens]] |
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: Baird-Titus | + | [[Category: Baird-Titus JM]] |
| - | [[Category: Doerdelmann | + | [[Category: Doerdelmann T]] |
| - | [[Category: Kojetin | + | [[Category: Kojetin DJ]] |
| - | [[Category: Rance | + | [[Category: Rance M]] |
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Revision as of 08:24, 18 January 2023
Solution Structure of the Pitx2 Homeodomain R24H mutant
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