Sandbox Reserved 1671
From Proteopedia
(Difference between revisions)
| Line 1: | Line 1: | ||
{{Sandbox_Reserved_BHall_Sp21}}<!-- PLEASE ADD YOUR CONTENT BELOW HERE --> | {{Sandbox_Reserved_BHall_Sp21}}<!-- PLEASE ADD YOUR CONTENT BELOW HERE --> | ||
| - | ==Your Heading Here ( | + | ==Your Heading Here (Ald-C)== |
<StructureSection load='1stp' size='340' side='right' caption='Caption for this structure' scene=''> | <StructureSection load='1stp' size='340' side='right' caption='Caption for this structure' scene=''> | ||
This is a default text for your page ''''''. Click above on '''edit this page''' to modify. Be careful with the < and > signs. | This is a default text for your page ''''''. Click above on '''edit this page''' to modify. Be careful with the < and > signs. | ||
| Line 9: | Line 9: | ||
== Function of your protein == | == Function of your protein == | ||
| - | The enzyme <scene name='87/873233/6x9l_2nd/1'>Ald-c</scene> is from a tomato plant. Ald-C is an aldehyde dehydrogenase which are known to preform many biological functions. This enzyme also functions as a long-chain aliphatic aldehyde dehydrogenase. It can detoxify highly reactive compounds such as aldehydes. In a plant they also help with cell wall ester biogenesis, and help plant when they | + | The enzyme <scene name='87/873233/6x9l_2nd/1'>Ald-c</scene> is from a tomato plant. Ald-C is an aldehyde dehydrogenase which are known to preform many biological functions. This enzyme also functions as a long-chain aliphatic aldehyde dehydrogenase. It can detoxify highly reactive compounds such as aldehydes. In a plant they also help with cell wall ester biogenesis, and help plant when they feel "stress" such as dehydration or environmental changes. |
== Biological relevance and broader implications == | == Biological relevance and broader implications == | ||
| - | The Pseudomonas syringae pant pathogen effects crops, it is relevant because farmers and people that work in the agriculture industry need to know of all the ways that their crops can get infected. Pseudomonas syringae makes the plants defenses against pathogens weak and it is more susceptible to get sick, by producing many different virulence factors such as parahormones, which are chemicals that are similar to the plants natural hormones but are not. | + | The Pseudomonas syringae pant pathogen effects crops, it is relevant because farmers and people that work in the agriculture industry need to know of all the ways that their crops can get infected. Pseudomonas syringae makes the plants defenses against pathogens weak and it is more susceptible to get sick, by producing many different virulence factors such as parahormones, which are chemicals that are similar to the plants natural hormones but are not. Pseudomonas syringae can destroy many different plants in different environments and temperatures, it can also survive and spread through the leaves. |
This paper is relevant to more areas in science because if someone want to make a defense chemical for Pseudomonas syringae they can use the chemistry in this paper to do so. There is a lost of valuable information that shows the chemistry, such as binding affinity. If someone is thinking about making a cure against Pseudomonas syringae they will need to know the characteristics of all the things that will bind well to it. | This paper is relevant to more areas in science because if someone want to make a defense chemical for Pseudomonas syringae they can use the chemistry in this paper to do so. There is a lost of valuable information that shows the chemistry, such as binding affinity. If someone is thinking about making a cure against Pseudomonas syringae they will need to know the characteristics of all the things that will bind well to it. | ||
| Line 24: | Line 24: | ||
there are <scene name='87/873233/Ligands/1'>2 ligands</scene> which are NAD+ and OYA.<scene name='87/873233/6x9l_2nd/1'>Text To Be Displayed</scene> | there are <scene name='87/873233/Ligands/1'>2 ligands</scene> which are NAD+ and OYA.<scene name='87/873233/6x9l_2nd/1'>Text To Be Displayed</scene> | ||
| - | <scene name='87/873233/14_other_aa/2'>19 other residues important for OYA binding.</scene> | + | The mutation was caused in the <scene name='87/873233/Mutant_ala_291/2'>cystine</scene> 291 position which is also one go the 4 catalytic residues. It was mutated to an alanine. |
| + | |||
| + | <scene name='87/873233/14_other_aa/2'>19 other residues important for OYA binding.</scene> | ||
== Structural highlights == | == Structural highlights == | ||
The octantal was the best substrate with the lowest Km and the highest affinity. | The octantal was the best substrate with the lowest Km and the highest affinity. | ||
| - | Ald-C is a homodimer. | + | Ald-C is also a homodimer. |
== Other important features == | == Other important features == | ||
Revision as of 20:20, 18 April 2021
| This Sandbox is Reserved from 01/25/2021 through 04/30/2021 for use in Biochemistry taught by Bonnie Hall at Grand View University, Des Moines, USA. This reservation includes Sandbox Reserved 1665 through Sandbox Reserved 1682. |
To get started:
More help: Help:Editing |
Your Heading Here (Ald-C)
| |||||||||||
References
Lee, S. G., Harline, K., Abar, O., Akadri, S. O., Bastian, A. G., Chen, H. S., Duan, M., Focht, C. M., Groziak, A. R., Kao, J., Kottapalli, J. S., Leong, M. C., Lin, J. J., Liu, R., Luo, J. E., Meyer, C. M., Mo, A. F., Pahng, S. H., Penna, V., Raciti, C. D., … Jez, J. M. (2020). The plant pathogen enzyme AldC is a long-chain aliphatic aldehyde dehydrogenase. The Journal of biological chemistry, 295(40), 13914–13926. https://doi.org/10.1074/jbc.RA120.014747
- ↑ Hanson, R. M., Prilusky, J., Renjian, Z., Nakane, T. and Sussman, J. L. (2013), JSmol and the Next-Generation Web-Based Representation of 3D Molecular Structure as Applied to Proteopedia. Isr. J. Chem., 53:207-216. doi:http://dx.doi.org/10.1002/ijch.201300024
- ↑ Herraez A. Biomolecules in the computer: Jmol to the rescue. Biochem Mol Biol Educ. 2006 Jul;34(4):255-61. doi: 10.1002/bmb.2006.494034042644. PMID:21638687 doi:10.1002/bmb.2006.494034042644
