Sandbox Reserved 1677
From Proteopedia
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== {{Sandbox_Reserved_BHall_Sp21}}<!-- PLEASE ADD YOUR CONTENT BELOW HERE --> | == {{Sandbox_Reserved_BHall_Sp21}}<!-- PLEASE ADD YOUR CONTENT BELOW HERE --> | ||
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- | + | There are <scene name='87/873239/4_catalytic_residue/1'>four catalytic amino acids</scene> in AldC. | |
- | + | Asn 159, Glu 257, Gly 288, Cys 291 | |
<scene name='87/873239/Nad_residues/1'>19 NAD+ Residues</scene> (binding site) | <scene name='87/873239/Nad_residues/1'>19 NAD+ Residues</scene> (binding site) | ||
- | + | Ile 155, Asn 159, Lys 182, Gly 219, Ile 233, Ser 236, Ala 239, leu 242, Glu 257, leu 258, Gly 259, Cys 291, Glu 391, Phe 393 | |
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Octanol Lingand (binding site) | Octanol Lingand (binding site) | ||
- | + | Trp 160 Tyr 163, Trp 450, Phe 456, Tyr 458, met 114, leu 118 | |
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https://proteopedia.org/wiki/images/4/48/Screen_Shot_2021-04-18_at_4.03.57_PM.png | https://proteopedia.org/wiki/images/4/48/Screen_Shot_2021-04-18_at_4.03.57_PM.png | ||
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== Structural highlights == | == Structural highlights == | ||
- | <scene name='87/873239/Cartoon_view/5'>AldC's secondary structure</scene> has two domains, hydrophobic and hydrophilic regions. The N-terminus of Aldc contains a central beta sheet surrounded by alpha helices which forms the NAD(H)-binding site. Additionally, around the C-terminus there is a mixture of alpha and beta domains which the cysteine residue and forms the aldehyde binding site. A small three stranded beta sheet domain facilitates aligomerization. There is an interdomain linker region that connects the N and C terminal domains of Aldc. | + | <scene name='87/873239/Cartoon_view/5'>AldC's secondary structure</scene> has two domains, hydrophobic and hydrophilic regions. |
+ | The N-terminus of Aldc contains a central beta sheet surrounded by alpha helices which forms the NAD(H)-binding site. | ||
+ | Additionally, around the C-terminus there is a mixture of alpha and beta domains which the cysteine residue and forms the aldehyde binding site. A small three stranded beta sheet domain facilitates aligomerization. | ||
+ | There is an interdomain linker region that connects the N and C terminal domains of Aldc. | ||
- | New cartoon View: tertiary/ Quaternary features | ||
<scene name='87/873239/Spacefill/1'>Space filling view</scene> shows how amino acids interacts with one another inside the protein. | <scene name='87/873239/Spacefill/1'>Space filling view</scene> shows how amino acids interacts with one another inside the protein. |
Revision as of 03:42, 19 April 2021
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This Sandbox is Reserved from 01/25/2021 through 04/30/2021 for use in Biochemistry taught by Bonnie Hall at Grand View University, Des Moines, USA. This reservation includes Sandbox Reserved 1665 through Sandbox Reserved 1682. |
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References
- ↑ Hanson, R. M., Prilusky, J., Renjian, Z., Nakane, T. and Sussman, J. L. (2013), JSmol and the Next-Generation Web-Based Representation of 3D Molecular Structure as Applied to Proteopedia. Isr. J. Chem., 53:207-216. doi:http://dx.doi.org/10.1002/ijch.201300024
- ↑ Herraez A. Biomolecules in the computer: Jmol to the rescue. Biochem Mol Biol Educ. 2006 Jul;34(4):255-61. doi: 10.1002/bmb.2006.494034042644. PMID:21638687 doi:10.1002/bmb.2006.494034042644
==