1ad6
From Proteopedia
(New page: 200px<br /> <applet load="1ad6" size="450" color="white" frame="true" align="right" spinBox="true" caption="1ad6, resolution 2.3Å" /> '''DOMAIN A OF HUMAN RE...) |
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| - | [[Image:1ad6.gif|left|200px]]<br /> | + | [[Image:1ad6.gif|left|200px]]<br /><applet load="1ad6" size="350" color="white" frame="true" align="right" spinBox="true" |
| - | <applet load="1ad6" size=" | + | |
caption="1ad6, resolution 2.3Å" /> | caption="1ad6, resolution 2.3Å" /> | ||
'''DOMAIN A OF HUMAN RETINOBLASTOMA TUMOR SUPPRESSOR'''<br /> | '''DOMAIN A OF HUMAN RETINOBLASTOMA TUMOR SUPPRESSOR'''<br /> | ||
==Overview== | ==Overview== | ||
| - | The pocket region of retinoblastoma tumour suppressor (Rb) is essential | + | The pocket region of retinoblastoma tumour suppressor (Rb) is essential for tumour suppressing activity. The Rb pocket is primarily composed of two domains, A and B. We have determined the X-ray crystal structure of domain A (residues 378-562) at 2.3 A resolution. Domain A consists of nine alpha-helices. The overall arrangement of helices in domain A is remarkably similar to the cyclin-box folds found in the crystal structures of cyclin A and TFIIB. This structure, along with domain B which is predicted to be homologous to the cyclin-box, suggests that the Rb pocket is composed of two cyclin-box fold domains. We present the structural/functional features of the Rb pocket, and the potential binding region for cellular or viral proteins within domain A. |
==Disease== | ==Disease== | ||
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==About this Structure== | ==About this Structure== | ||
| - | 1AD6 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http:// | + | 1AD6 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1AD6 OCA]. |
==Reference== | ==Reference== | ||
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[[Category: Single protein]] | [[Category: Single protein]] | ||
[[Category: Cho, Y.]] | [[Category: Cho, Y.]] | ||
| - | [[Category: Kim, H | + | [[Category: Kim, H Y.]] |
[[Category: dna-binding]] | [[Category: dna-binding]] | ||
[[Category: transcription regulation]] | [[Category: transcription regulation]] | ||
[[Category: tumor suppressor]] | [[Category: tumor suppressor]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 11:43:23 2008'' |
Revision as of 09:43, 21 February 2008
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DOMAIN A OF HUMAN RETINOBLASTOMA TUMOR SUPPRESSOR
Contents |
Overview
The pocket region of retinoblastoma tumour suppressor (Rb) is essential for tumour suppressing activity. The Rb pocket is primarily composed of two domains, A and B. We have determined the X-ray crystal structure of domain A (residues 378-562) at 2.3 A resolution. Domain A consists of nine alpha-helices. The overall arrangement of helices in domain A is remarkably similar to the cyclin-box folds found in the crystal structures of cyclin A and TFIIB. This structure, along with domain B which is predicted to be homologous to the cyclin-box, suggests that the Rb pocket is composed of two cyclin-box fold domains. We present the structural/functional features of the Rb pocket, and the potential binding region for cellular or viral proteins within domain A.
Disease
Known diseases associated with this structure: Bladder cancer OMIM:[180200], Osteosarcoma OMIM:[180200], Pinealoma with bilateral retinoblastoma OMIM:[180200], Retinoblastoma OMIM:[180200]
About this Structure
1AD6 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
Structural similarity between the pocket region of retinoblastoma tumour suppressor and the cyclin-box., Kim HY, Cho Y, Nat Struct Biol. 1997 May;4(5):390-5. PMID:9145110
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