7atz
From Proteopedia
(Difference between revisions)
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==G-quadruplex with V-shaped loop from the first repeat of KCNN4 minisatellite== | ==G-quadruplex with V-shaped loop from the first repeat of KCNN4 minisatellite== | ||
| - | <StructureSection load='7atz' size='340' side='right'caption='[[7atz]]' scene=''> | + | <StructureSection load='7atz' size='340' side='right'caption='[[7atz]], [[NMR_Ensembles_of_Models | 10 NMR models]]' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>Full | + | <table><tr><td colspan='2'>[[7atz]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7ATZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7ATZ FirstGlance]. <br> |
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7atz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7atz OCA], [https://pdbe.org/7atz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7atz RCSB], [https://www.ebi.ac.uk/pdbsum/7atz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7atz ProSAT]</span></td></tr> | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7atz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7atz OCA], [https://pdbe.org/7atz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7atz RCSB], [https://www.ebi.ac.uk/pdbsum/7atz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7atz ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | The KCNN4 gene encoding a potassium channel protein whose expression has been correlated with tumor progression was found to comprise a guanine-rich minisatellite region with the ability to form a putative G-quadruplex (G4). Given the suggested regulatory role of G4s in gene expression, G-quadruplex formation for the polymorphic first repeat of the minisatellite was studied by nuclear magnetic resonance spectroscopy. A stable G-quadruplex of a truncated mutant sequence was shown to represent one of several coexisting species of the wild-type sequence. The high-resolution structure features a noncanonical G4 with a broken G-column and a V-shaped loop. The presence of a 3'-flanking thymidine interacting with the lateral loop preceding the V loop seems to be critical for the formation of this G4 topology. On the contrary, an additional 5'-flanking residue disfavored but still allowed folding into the V-loop structure. The latter may therefore serve as a putative therapeutic target in strategies for G4-based modulation of KCNN4 expression. | ||
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| + | First Tandem Repeat of a Potassium Channel KCNN4 Minisatellite Folds into a V-Loop G-Quadruplex Structure.,Vianney YM, Weisz K Biochemistry. 2021 Apr 12. doi: 10.1021/acs.biochem.1c00043. PMID:33844501<ref>PMID:33844501</ref> | ||
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| + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
| + | </div> | ||
| + | <div class="pdbe-citations 7atz" style="background-color:#fffaf0;"></div> | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: Vianney | + | [[Category: Vianney, Y M]] |
| - | [[Category: Weisz K]] | + | [[Category: Weisz, K]] |
| + | [[Category: Dna]] | ||
| + | [[Category: G-quadruplex]] | ||
| + | [[Category: V-loop]] | ||
Current revision
G-quadruplex with V-shaped loop from the first repeat of KCNN4 minisatellite
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Categories: Large Structures | Vianney, Y M | Weisz, K | Dna | G-quadruplex | V-loop
