7bx2
From Proteopedia
(Difference between revisions)
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==The solution NMR structure of VV14 peptide in the presence of Deuterated SDS micelle.== | ==The solution NMR structure of VV14 peptide in the presence of Deuterated SDS micelle.== | ||
| - | <StructureSection load='7bx2' size='340' side='right'caption='[[7bx2]]' scene=''> | + | <StructureSection load='7bx2' size='340' side='right'caption='[[7bx2]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>Full | + | <table><tr><td colspan='2'>[[7bx2]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7BX2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7BX2 FirstGlance]. <br> |
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7bx2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7bx2 OCA], [https://pdbe.org/7bx2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7bx2 RCSB], [https://www.ebi.ac.uk/pdbsum/7bx2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7bx2 ProSAT]</span></td></tr> | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7bx2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7bx2 OCA], [https://pdbe.org/7bx2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7bx2 RCSB], [https://www.ebi.ac.uk/pdbsum/7bx2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7bx2 ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Herein we report the efficacy and toxicity of three de novo designed cationic antimicrobial peptides (AMPs) LL-14, VV-14 and betabeta-14, where side chains of the hydrophobic amino acids were reduced gradually. The AMPs showed broad-spectrum antimicrobial activity against three pathogens from the ESKAPE group and two fungal strains. This study showed that side chains which are either too long or too short increase toxicity and lower antimicrobial activity, respectively. VV-14 was found to be non-cytotoxic and highly potent under physiological salt concentrations against several pathogens, especially Salmonella typhi TY2. These AMPs acted via membrane deformation, depolarization, and lysis. The activity of the AMPs is related to their ability to take on amphipathic helical conformations in the presence of microbial membrane mimics. Among AMPs with the same charge, hydrophobic interactions between the side chains of the residues with cell membrane lipids determine their antimicrobial potency and cytotoxicity. Strikingly, an optimum hydrophobic interaction is the crux of generating highly potent non-cytotoxic AMPs. | ||
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| + | Effect of Secondary Structure and Side Chain Length of Hydrophobic Amino Acid Residues on the Antimicrobial Activity and Toxicity of 14-Residue-Long de novo AMPs.,Pandit G, Chowdhury N, Abdul Mohid S, Bidkar AP, Bhunia A, Chatterjee S ChemMedChem. 2021 Jan 19;16(2):355-367. doi: 10.1002/cmdc.202000550. Epub 2020, Oct 22. PMID:33026188<ref>PMID:33026188</ref> | ||
| + | |||
| + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
| + | </div> | ||
| + | <div class="pdbe-citations 7bx2" style="background-color:#fffaf0;"></div> | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: Bhunia A]] | + | [[Category: Bhunia, A]] |
| - | [[Category: Chowdhury N]] | + | [[Category: Chowdhury, N]] |
| - | [[Category: Mohid | + | [[Category: Mohid, S A]] |
| + | [[Category: Alpha helix]] | ||
| + | [[Category: Antimicrobial peptide]] | ||
| + | [[Category: Antimicrobial protein]] | ||
| + | [[Category: Sds micelle]] | ||
| + | [[Category: Structure from cyana 2 1]] | ||
Revision as of 15:56, 3 November 2021
The solution NMR structure of VV14 peptide in the presence of Deuterated SDS micelle.
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