7lqs
From Proteopedia
(Difference between revisions)
| Line 3: | Line 3: | ||
<StructureSection load='7lqs' size='340' side='right'caption='[[7lqs]]' scene=''> | <StructureSection load='7lqs' size='340' side='right'caption='[[7lqs]]' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>Full | + | <table><tr><td colspan='2'>Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7LQS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7LQS FirstGlance]. <br> |
| - | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7lqs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7lqs OCA], [https://pdbe.org/7lqs PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7lqs RCSB], [https://www.ebi.ac.uk/pdbsum/7lqs PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7lqs ProSAT]</span></td></tr> | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR, 20 models</td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7lqs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7lqs OCA], [https://pdbe.org/7lqs PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7lqs RCSB], [https://www.ebi.ac.uk/pdbsum/7lqs PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7lqs ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Cone snails are venomous marine predators that rely on fast-acting venom to subdue their prey and defend against aggressors. The conotoxins produced in the venom gland are small disulfide-rich peptides with high affinity and selectivity for their pharmacological targets. A dominant group comprises alpha-conotoxins, targeting nicotinic acetylcholine receptors. Here, we report on the synthesis, structure determination and biological activity of a novel alpha-conotoxin, CIC, found in the predatory venom of the piscivorous species Conus catus and its truncated mutant Delta-CIC. CIC is a 4/7 alpha-conotoxin with an unusual extended N-terminal tail. High-resolution NMR spectroscopy shows a major influence of the N-terminal tail on the apparent rigidity of the three-dimensional structure of CIC compared to the more flexible Delta-CIC. Surprisingly, this effect on the structure does not alter the biological activity, since both peptides selectively inhibit alpha3beta2 and alpha6/alpha3beta2beta3 nAChRs with almost identical sub- to low micromolar inhibition constants. Our results suggest that the N-terminal part of alpha-conotoxins can accommodate chemical modifications without affecting their pharmacology. | ||
| + | |||
| + | Synthesis, Structural and Pharmacological Characterizations of CIC, a Novel alpha-Conotoxin with an Extended N-Terminal Tail.,Giribaldi J, Haufe Y, Evans ERJ, Wilson DT, Daly NL, Enjalbal C, Nicke A, Dutertre S Mar Drugs. 2021 Mar 2;19(3). pii: md19030141. doi: 10.3390/md19030141. PMID:33801301<ref>PMID:33801301</ref> | ||
| + | |||
| + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
| + | </div> | ||
| + | <div class="pdbe-citations 7lqs" style="background-color:#fffaf0;"></div> | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
Current revision
Structure of truncated conotoxin CIC
| |||||||||||
