7meq
From Proteopedia
(Difference between revisions)
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==Crystal structure of human TMPRSS2 in complex with Nafamostat== | ==Crystal structure of human TMPRSS2 in complex with Nafamostat== | ||
| - | <StructureSection load='7meq' size='340' side='right'caption='[[7meq]]' scene=''> | + | <StructureSection load='7meq' size='340' side='right'caption='[[7meq]], [[Resolution|resolution]] 1.95Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7MEQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7MEQ FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[7meq]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7MEQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7MEQ FirstGlance]. <br> |
| - | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7meq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7meq OCA], [https://pdbe.org/7meq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7meq RCSB], [https://www.ebi.ac.uk/pdbsum/7meq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7meq ProSAT]</span></td></tr> | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GBS:4-GUANIDINOBENZOIC+ACID'>GBS</scene>, <scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr> |
| + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">TMPRSS2, PRSS10 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7meq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7meq OCA], [https://pdbe.org/7meq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7meq RCSB], [https://www.ebi.ac.uk/pdbsum/7meq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7meq ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | == Function == | ||
| + | [[https://www.uniprot.org/uniprot/TMPS2_HUMAN TMPS2_HUMAN]] Plasma membrane-anchored serine protease that participates in proteolytic cascades of relevance for the normal physiologic function of the prostate (PubMed:25122198). Androgen-induced TMPRSS2 activates several substrates that include pro-hepatocyte growth factor/HGF, the protease activated receptor-2/F2RL1 or matriptase/ST14 leading to extracellular matrix disruption and metastasis of prostate cancer cells (PubMed:15537383, PubMed:26018085, PubMed:25122198). In addition, activates trigeminal neurons and contribute to both spontaneous pain and mechanical allodynia (By similarity).[UniProtKB:Q9JIQ8]<ref>PMID:15537383</ref> <ref>PMID:25122198</ref> <ref>PMID:26018085</ref> (Microbial infection) Facilitates human coronaviruses SARS-CoV and SARS-CoV-2 infections via two independent mechanisms, proteolytic cleavage of ACE2 receptor which promotes viral uptake, and cleavage of coronavirus spike glycoproteins which activates the glycoprotein for host cell entry (PubMed:24227843, PubMed:32142651, PubMed:32404436). Proteolytically cleaves and activates the spike glycoproteins of human coronavirus 229E (HCoV-229E) and human coronavirus EMC (HCoV-EMC) and the fusion glycoproteins F0 of Sendai virus (SeV), human metapneumovirus (HMPV), human parainfluenza 1, 2, 3, 4a and 4b viruses (HPIV). Essential for spread and pathogenesis of influenza A virus (strains H1N1, H3N2 and H7N9); involved in proteolytic cleavage and activation of hemagglutinin (HA) protein which is essential for viral infectivity.<ref>PMID:21068237</ref> <ref>PMID:21325420</ref> <ref>PMID:23536651</ref> <ref>PMID:23966399</ref> <ref>PMID:24027332</ref> <ref>PMID:24227843</ref> <ref>PMID:32142651</ref> <ref>PMID:32404436</ref> | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| + | [[Category: Human]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: Arrowsmith | + | [[Category: Arrowsmith, C H]] |
| - | [[Category: Beldar S]] | + | [[Category: Beldar, S]] |
| - | [[Category: Benard F]] | + | [[Category: Benard, F]] |
| - | [[Category: Edwards | + | [[Category: Edwards, A M]] |
| - | [[Category: Fraser B]] | + | [[Category: Fraser, B]] |
| - | [[Category: Halabelian L]] | + | [[Category: Halabelian, L]] |
| - | [[Category: Hutchinson A]] | + | [[Category: Hutchinson, A]] |
| - | [[Category: Li Y]] | + | [[Category: Li, Y]] |
| - | [[Category: Seitova A]] | + | [[Category: Structural genomic]] |
| + | [[Category: Seitova, A]] | ||
| + | [[Category: Covid19]] | ||
| + | [[Category: Hydrolase-hydrolase inhibitor complex]] | ||
| + | [[Category: Protease]] | ||
Revision as of 15:59, 3 November 2021
Crystal structure of human TMPRSS2 in complex with Nafamostat
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