We apologize for Proteopedia being slow to respond. For the past two years, a new implementation of Proteopedia has been being built. Soon, it will replace this 18-year old system. All existing content will be moved to the new system at a date that will be announced here.
6lxg
From Proteopedia
(Difference between revisions)
| Line 1: | Line 1: | ||
==NMR solution structure of regulatory ACT domain of the Mycobacterium tuberculosis Rel protein== | ==NMR solution structure of regulatory ACT domain of the Mycobacterium tuberculosis Rel protein== | ||
| - | <StructureSection load='6lxg' size='340' side='right'caption='[[6lxg | + | <StructureSection load='6lxg' size='340' side='right'caption='[[6lxg]]' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[6lxg]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/ | + | <table><tr><td colspan='2'>[[6lxg]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6LXG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6LXG FirstGlance]. <br> |
| - | </td></tr> | + | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6lxg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6lxg OCA], [https://pdbe.org/6lxg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6lxg RCSB], [https://www.ebi.ac.uk/pdbsum/6lxg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6lxg ProSAT]</span></td></tr> |
| - | + | ||
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6lxg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6lxg OCA], [https://pdbe.org/6lxg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6lxg RCSB], [https://www.ebi.ac.uk/pdbsum/6lxg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6lxg ProSAT]</span></td></tr> | + | |
</table> | </table> | ||
== Function == | == Function == | ||
| - | + | [https://www.uniprot.org/uniprot/RELA_MYCTU RELA_MYCTU] In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. This enzyme catalyzes both the formation of pppGpp, which is then hydrolyzed to form ppGpp, as well as the hydrolysis of ppGpp. RelA is probably a key factor in the pathogenesis of M.tuberculosis as it regulates the intracellular concentrations of (p)ppGpp.<ref>PMID:10375643</ref> <ref>PMID:10940033</ref> | |
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
| Line 23: | Line 21: | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: GTP diphosphokinase]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: Gruber, G]] | ||
| - | [[Category: Manimekalai, M S.S]] | ||
| - | [[Category: Shin, J]] | ||
| - | [[Category: Singal, B]] | ||
| - | [[Category: Branched chain amino acid]] | ||
[[Category: Mycobacterium tuberculosis]] | [[Category: Mycobacterium tuberculosis]] | ||
| - | [[Category: | + | [[Category: Gruber G]] |
| - | [[Category: | + | [[Category: Manimekalai MSS]] |
| - | [[Category: | + | [[Category: Shin J]] |
| + | [[Category: Singal B]] | ||
Current revision
NMR solution structure of regulatory ACT domain of the Mycobacterium tuberculosis Rel protein
| |||||||||||
