This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
1jzp
From Proteopedia
(Difference between revisions)
| Line 1: | Line 1: | ||
==Modified Peptide A (D18-A1) of the Rabbit Skeletal Dihydropyridine Receptor== | ==Modified Peptide A (D18-A1) of the Rabbit Skeletal Dihydropyridine Receptor== | ||
| - | <StructureSection load='1jzp' size='340' side='right'caption='[[1jzp | + | <StructureSection load='1jzp' size='340' side='right'caption='[[1jzp]]' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[1jzp]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JZP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1JZP FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[1jzp]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Oryctolagus_cuniculus Oryctolagus cuniculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1JZP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1JZP FirstGlance]. <br> |
| - | </td></tr><tr id=' | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> |
| - | <tr id=' | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr> |
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1jzp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jzp OCA], [https://pdbe.org/1jzp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1jzp RCSB], [https://www.ebi.ac.uk/pdbsum/1jzp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1jzp ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1jzp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1jzp OCA], [https://pdbe.org/1jzp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1jzp RCSB], [https://www.ebi.ac.uk/pdbsum/1jzp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1jzp ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/CAC1S_RABIT CAC1S_RABIT] Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1S gives rise to L-type calcium currents. Long-lasting (L-type) calcium channels belong to the 'high-voltage activated' (HVA) group. They are blocked by dihydropyridines (DHP), phenylalkylamines, benzothiazepines, and by omega-agatoxin-IIIA (omega-Aga-IIIA). They are however insensitive to omega-conotoxin-GVIA (omega-CTx-GVIA) and omega-agatoxin-IVA (omega-Aga-IVA). Calcium channels containing the alpha-1S subunit play an important role in excitation-contraction coupling in skeletal muscle. | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
| Line 22: | Line 24: | ||
</StructureSection> | </StructureSection> | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: Casarotto | + | [[Category: Oryctolagus cuniculus]] |
| - | [[Category: Dulhunty | + | [[Category: Casarotto MG]] |
| - | [[Category: Green | + | [[Category: Dulhunty AF]] |
| - | [[Category: Pace | + | [[Category: Green D]] |
| - | [[Category: Sakowska | + | [[Category: Pace S]] |
| - | + | [[Category: Sakowska M]] | |
| - | + | ||
| - | + | ||
| - | + | ||
Current revision
Modified Peptide A (D18-A1) of the Rabbit Skeletal Dihydropyridine Receptor
| |||||||||||
