1e8q

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{{STRUCTURE_1e8q| PDB=1e8q | SCENE= }}
{{STRUCTURE_1e8q| PDB=1e8q | SCENE= }}
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'''CHARACTERISATION OF THE CELLULOSE DOCKING DOMAIN FROM PIROMYCES EQUI'''
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===CHARACTERISATION OF THE CELLULOSE DOCKING DOMAIN FROM PIROMYCES EQUI===
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==Overview==
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The recycling of photosynthetically fixed carbon in plant cell walls is a key microbial process. In anaerobes, the degradation is carried out by a high molecular weight multifunctional complex termed the cellulosome. This consists of a number of independent enzyme components, each of which contains a conserved dockerin domain, which functions to bind the enzyme to a cohesin domain within the protein scaffoldin protein. Here we describe the first three-dimensional structure of a fungal dockerin, the N-terminal dockerin of Cel45A from the anaerobic fungus Piromyces equi. The structure contains a novel fold of 42 residues. The ligand binding site consists of residues Trp 35, Tyr 8 and Asp 23, which are conserved in all fungal dockerins. The binding site is on the opposite side of the N- and C-termini of the molecule, implying that tandem dockerin domains, seen in the majority of anaerobic fungal plant cell wall degrading enzymes, could present multiple simultaneous binding sites and, therefore, permit tailoring of binding to catalytic demands.
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(as it appears on PubMed at http://www.pubmed.gov), where 11524680 is the PubMed ID number.
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{{ABSTRACT_PUBMED_11524680}}
==About this Structure==
==About this Structure==
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1E8Q is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Piromyces_equi Piromyces equi]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1E8Q OCA].
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1E8Q is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Piromyces_equi Piromyces equi]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1E8Q OCA].
==Reference==
==Reference==
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[[Category: Cellulase]]
[[Category: Cellulase]]
[[Category: Cellulose docking domain]]
[[Category: Cellulose docking domain]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 14:48:07 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 00:19:41 2008''

Revision as of 21:19, 30 June 2008

Image:1e8q.png

Template:STRUCTURE 1e8q

CHARACTERISATION OF THE CELLULOSE DOCKING DOMAIN FROM PIROMYCES EQUI

Template:ABSTRACT PUBMED 11524680

About this Structure

1E8Q is a Single protein structure of sequence from Piromyces equi. Full experimental information is available from OCA.

Reference

Characterization of a cellulosome dockerin domain from the anaerobic fungus Piromyces equi., Raghothama S, Eberhardt RY, Simpson P, Wigelsworth D, White P, Hazlewood GP, Nagy T, Gilbert HJ, Williamson MP, Nat Struct Biol. 2001 Sep;8(9):775-8. PMID:11524680

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