1e91

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[[Image:1e91.gif|left|200px]]
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{{STRUCTURE_1e91| PDB=1e91 | SCENE= }}
{{STRUCTURE_1e91| PDB=1e91 | SCENE= }}
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'''STRUCTURE OF THE COMPLEX OF THE MAD1-SIN3B INTERACTION DOMAINS'''
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===STRUCTURE OF THE COMPLEX OF THE MAD1-SIN3B INTERACTION DOMAINS===
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==Overview==
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Sin3A or Sin3B are components of a corepressor complex that mediates repression by transcription factors such as the helix-loop-helix proteins Mad and Mxi. Members of the Mad/Mxi family of repressors play important roles in the transition between proliferation and differentiation by down-regulating the expression of genes that are activated by the proto-oncogene product Myc. Here, we report the solution structure of the second paired amphipathic helix (PAH) domain (PAH2) of Sin3B in complex with a peptide comprising the N-terminal region of Mad1. This complex exhibits a novel interaction fold for which we propose the name 'wedged helical bundle'. Four alpha-helices of PAH2 form a hydrophobic cleft that accommodates an amphipathic Mad1 alpha-helix. Our data further show that, upon binding Mad1, secondary structure elements of PAH2 are stabilized. The PAH2-Mad1 structure provides the basis for determining the principles of protein interaction and selectivity involving PAH domains.
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(as it appears on PubMed at http://www.pubmed.gov), where 11101889 is the PubMed ID number.
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{{ABSTRACT_PUBMED_11101889}}
==About this Structure==
==About this Structure==
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1E91 is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1E91 OCA].
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1E91 is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1E91 OCA].
==Reference==
==Reference==
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[[Category: Protein-protein interaction]]
[[Category: Protein-protein interaction]]
[[Category: Sin3]]
[[Category: Sin3]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 14:48:49 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 00:20:37 2008''

Revision as of 21:20, 30 June 2008

Image:1e91.png

Template:STRUCTURE 1e91

STRUCTURE OF THE COMPLEX OF THE MAD1-SIN3B INTERACTION DOMAINS

Template:ABSTRACT PUBMED 11101889

About this Structure

1E91 is a Protein complex structure of sequences from Homo sapiens and Mus musculus. Full experimental information is available from OCA.

Reference

The Mad1-Sin3B interaction involves a novel helical fold., Spronk CA, Tessari M, Kaan AM, Jansen JF, Vermeulen M, Stunnenberg HG, Vuister GW, Nat Struct Biol. 2000 Dec;7(12):1100-4. PMID:11101889

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