Sandbox GGC16
From Proteopedia
(Difference between revisions)
| Line 1: | Line 1: | ||
==PU.1== | ==PU.1== | ||
<StructureSection load='1PUE' size='340' side='right' caption='Caption for this structure' scene=''> | <StructureSection load='1PUE' size='340' side='right' caption='Caption for this structure' scene=''> | ||
| - | PU.1 is a hematopoietic transcription factor. It specifically regulates transcription of | + | PU.1 is a hematopoietic transcription factor. It specifically regulates transcription of genes specific to myeloid and lymphoid cells, ultimately leading to cellular differentiation. |
| - | == Name == | + | == Name and Location == |
The name PU.1 comes from the protein's binding interactions with a purine-rich DNA sequence. | The name PU.1 comes from the protein's binding interactions with a purine-rich DNA sequence. | ||
<scene name='87/874948/Earpurinerich/2'>Bases at Interface</scene> | <scene name='87/874948/Earpurinerich/2'>Bases at Interface</scene> | ||
| + | The protein resides in the nucleus. | ||
| - | == Function == | ||
===Binding Domain=== | ===Binding Domain=== | ||
| - | <scene name='87/874948/ | + | <scene name='87/874948/Earbindingresiduesbest/1'>Residues at Binding Domain</scene> |
| + | Ets binding domain is conserved across the Ets family of proteins. | ||
| + | Binding domain is positively charged. Residues most closely interacting with DNA include Arginine and Lysine. | ||
== Disease == | == Disease == | ||
| + | PU.1 has been identified as an oncogene. Mutations have been identified in patients with leukemias and lymphomas. Interestingly, the mutations are not always identified within the binding site. | ||
| + | |||
| + | == PEST domain == | ||
| - | == Relevance == | ||
== Structural highlights == | == Structural highlights == | ||
Revision as of 15:44, 24 April 2021
PU.1
| |||||||||||
