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Sandbox GGC16

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== Name and Location ==
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== Function ==
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The name PU.1 comes from the protein's binding interactions with a purine-rich DNA sequence.
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Within the nucleus, PU.1 activates transcription of lymphoid genes by binding DNA during hematopoiesis.<scene name='87/874948/Earpurinerich/2'>Bases at Interface</scene> The name PU.1 comes from the protein's binding interactions with a purine-rich DNA sequence.
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<scene name='87/874948/Earpurinerich/2'>Bases at Interface</scene>
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The protein resides in the nucleus.
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=== Activation ===
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A post-translational modification of PU.1 occurs at a serine residue (residue 41). This phosphorylation by protein kinase B (AKT) induces PU.1 activation.<ref>Rieske, P., &amp; Pongubala, J. M. R. (2001). AKT Induces Transcriptional Activity of PU.1 through Phosphorylation-mediated Modifications within Its Transactivation Domain. Journal of Biological Chemistry, 276(11), 8460–8468. https://doi.org/10.1074/jbc.m007482200</ref>

Revision as of 18:53, 24 April 2021

PU.1

Caption for this structure

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References

  1. ↑ UniProt ConsortiumEuropean Bioinformatics InstituteProtein Information ResourceSIB Swiss Institute of Bioinformatics. (2021, April 7). Transcription factor PU.1. UniProt ConsortiumEuropean Bioinformatics InstituteProtein Information ResourceSIB Swiss Institute of Bioinformatics. https://www.uniprot.org/uniprot/P17947.
  2. ↑ Rieske, P., & Pongubala, J. M. R. (2001). AKT Induces Transcriptional Activity of PU.1 through Phosphorylation-mediated Modifications within Its Transactivation Domain. Journal of Biological Chemistry, 276(11), 8460–8468. https://doi.org/10.1074/jbc.m007482200
  3. ↑ Kodandapani, R., Pio, F., Ni, CZ. et al. A new pattern for helix–turn–helix recognition revealed by the PU.l ETS–domain–DNA complex. Nature 380, 456–460 (1996). https://doi.org/10.1038/380456a0
  4. ↑ Mueller, B. U. Heterozygous PU.1 Mutations Are Associated with Acute Myeloid Leukemia. Blood. 2003, 101(5), 2074–2074.
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