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Sandbox GGC16
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== Function == | == Function == | ||
| - | + | <scene name='87/874948/Earpurinerich/2'>Bases at Interface</scene> Within the nucleus, PU.1 activates transcription of lymphoid genes by binding DNA during hematopoiesis. The name PU.1 comes from the protein's binding interactions with a purine-rich DNA sequence. | |
=== Activation === | === Activation === | ||
Revision as of 19:00, 24 April 2021
PU.1
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References
- ↑ UniProt ConsortiumEuropean Bioinformatics InstituteProtein Information ResourceSIB Swiss Institute of Bioinformatics. (2021, April 7). Transcription factor PU.1. UniProt ConsortiumEuropean Bioinformatics InstituteProtein Information ResourceSIB Swiss Institute of Bioinformatics. https://www.uniprot.org/uniprot/P17947.
- ↑ Rieske, P., & Pongubala, J. M. R. (2001). AKT Induces Transcriptional Activity of PU.1 through Phosphorylation-mediated Modifications within Its Transactivation Domain. Journal of Biological Chemistry, 276(11), 8460–8468. https://doi.org/10.1074/jbc.m007482200
- ↑ Kodandapani, R., Pio, F., Ni, CZ. et al. A new pattern for helix–turn–helix recognition revealed by the PU.l ETS–domain–DNA complex. Nature 380, 456–460 (1996). https://doi.org/10.1038/380456a0
- ↑ Mueller, B. U. Heterozygous PU.1 Mutations Are Associated with Acute Myeloid Leukemia. Blood. 2003, 101(5), 2074–2074.
