Sandbox GGC17

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<StructureSection load='4RMB' size='340' side='right' caption='Keratin 4 protein' scene=''>
<StructureSection load='4RMB' size='340' side='right' caption='Keratin 4 protein' scene=''>
This is a default text for your page. Click above on '''edit this page''' to modify. Be careful with the &lt; and &gt; signs.
This is a default text for your page. Click above on '''edit this page''' to modify. Be careful with the &lt; and &gt; signs.
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You may include any references to papers as in: the use of JSmol in Proteopedia <ref>DOI 10.1016/j.ijbiomac.201412048</ref> or to the article describing Jmol <ref>PMID:2117679</ref> to the rescue.
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You may include any references to papers as in: the use of JSmol in Proteopedia <ref>DOI 10.1128/IAI.00717-07</ref> or to the article describing Jmol <ref>PMID:2117679</ref> to the rescue.
== Function ==
== Function ==
KRT 4 gene is going to provide enough information to create the protein Keratin 4. Keratins are the main groups for tough fibrous proteins that will form the framework of epithelial cells. Epithelial cells line up the surfaces and cavities intended for the body. Keratin 4 is usually found within the moist lining of your mouth, nose, esophagus, anus, and gentitals.
KRT 4 gene is going to provide enough information to create the protein Keratin 4. Keratins are the main groups for tough fibrous proteins that will form the framework of epithelial cells. Epithelial cells line up the surfaces and cavities intended for the body. Keratin 4 is usually found within the moist lining of your mouth, nose, esophagus, anus, and gentitals.
== Disease ==
== Disease ==
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The disease that Keratin 4 causes is white sponge nevus. White sponge nevus is an autosomal dominant disease which is caused by amutation of a certain keratin genes. White sponge nevus is going to be a main componenet for a group of inherited diseases that are going to provide a white bilateral, keratinized apperance typically appearing on the buccal mucosa. [[Image:joddd-3-70-g001.jpg]] White sponge nevus lesions on the inside of the lips.<ref>DOI 10.5681/jodd.2009.017</ref>.
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The disease that Keratin 4 causes is white sponge nevus. White sponge nevus is an autosomal dominant disease which is caused by amutation of a certain keratin genes. White sponge nevus is going to be a main componenet for a group of inherited diseases that are going to provide a white bilateral, keratinized apperance typically appearing on the buccal mucosa. [[Image:joddd-3-70-g001.jpg]] White sponge nevus lesions on the inside of the lips.<ref>DOI 10.5681/jodd.2009017</ref>.
== Relevance ==
== Relevance ==
The two way parallel beta-sheet is where the C-terminal strand of one monomer is being positioned and anti-parallel to the N-terminal strand of the main adjacent monomer and this arrangement is not seen so far in any of the homologous structures. This is the <scene name='87/874949/00rainbow_ribbon/1'>Keratin 4 protein</scene>.
The two way parallel beta-sheet is where the C-terminal strand of one monomer is being positioned and anti-parallel to the N-terminal strand of the main adjacent monomer and this arrangement is not seen so far in any of the homologous structures. This is the <scene name='87/874949/00rainbow_ribbon/1'>Keratin 4 protein</scene>.

Revision as of 18:34, 26 April 2021

Keratin 4

Keratin 4 protein

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References

  1. Samen U, Eikmanns BJ, Reinscheid DJ, Borges F. The surface protein Srr-1 of Streptococcus agalactiae binds human keratin 4 and promotes adherence to epithelial HEp-2 cells. Infect Immun. 2007 Nov;75(11):5405-14. doi: 10.1128/IAI.00717-07. Epub 2007 Aug, 20. PMID:17709412 doi:http://dx.doi.org/10.1128/IAI.00717-07
  2. Moore PS, Hierholzer J, DeWitt W, Gouan K, Djore D, Lippeveld T, Plikaytis B, Broome CV. Respiratory viruses and mycoplasma as cofactors for epidemic group A meningococcal meningitis. JAMA. 1990 Sep 12;264(10):1271-5. PMID:2117679
  3. doi: https://dx.doi.org/10.5681/jodd.2009017
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