User:Maggie Stopa/Sandbox 1

From Proteopedia

< User:Maggie Stopa(Difference between revisions)
Jump to: navigation, search
Current revision (03:02, 28 April 2021) (edit) (undo)
 
Line 5: Line 5:
It should be noted that the PDB: 6OB0 was used to synthesize the following images.
It should be noted that the PDB: 6OB0 was used to synthesize the following images.
-
<scene name='87/877513/Original_scene/1'>Lipoprotein Lipase</scene>(LPL) is an important enzyme for the breakdown of triglycerides in the body (Figure 1).<ref name=”Arora”>PMID:31072929</ref> [[Image:Simple_mech.png|400 px|right|thumb|Figure 1: breakdown of a triglyceride into a diglyceride and creation of one free fatty acid by LPL]] A [http://en.wikipedia.org/wiki/Lipase lipase] is an enzyme that is capable of catalyzing the [http://en.wikipedia.org/wiki/Hydrolysis hydrolysis] of fats/lipids which are consumed through oils. It is encoded by the [http://www.genecards.org/cgi-bin/carddisp.pl?gene=LPL p22 region in chromosome 8]. Once synthesized, it is secreted into the interstitial space in several tissues. The main site of action for <scene name='87/877513/Original_scene/1'>LPL</scene> is in the [http://www.pnas.org/content/pnas/116/5/1480/F1.large.jpg capillary lumen] within muscle and adipose tissues.<ref name=”Birrane”>PMID:30559189</ref> The function of this lipase is to hydrolyze [http://en.wikipedia.org/wiki/Triglyceride triglycerides] of very-low-density lipoproteins ([http://qph.fs.quoracdn.net/main-qimg-8e874e647baeb69b00203c47165247e2 VLDL]) and to aid in the delivery of lipid nutrients to vital tissues.<ref name=”Birrane”>PMID:30559189</ref> The enzyme is commonly found on the surface of cells that line blood capillaries. Two different lipoproteins are essential to break down triglycerides. One of the lipoproteins is utilized to transport fat into the bloodstream from different organs.<ref name=”Arora”>PMID:31072929</ref> The lipoproteins essential, in the transport of fat from the intestine are referred to as [http://en.wikipedia.org/wiki/Chylomicron chylomicrons]. VLDL are utilized in carrying triglycerides from the liver into the bloodstream. The hydrolysis of triglycerides by lipoprotein lipase results in fat molecules being used by the body as energy or stored in fatty tissue. <ref name=”Arora”>PMID:31072929</ref><ref name=”Mead”>PMID:12483461</ref>
+
<scene name='87/877513/Original_scene/1'>Lipoprotein Lipase</scene>(LPL) is an important enzyme for the breakdown of triglycerides in the body (Figure 1).<ref name=”Arora”>PMID:31072929</ref> [[Image:Simple_mech.png|400 px|right|thumb|Figure 1: breakdown of a triglyceride into a diglyceride and creation of one free fatty acid by LPL]] A [http://en.wikipedia.org/wiki/Lipase lipase] is an enzyme that is capable of catalyzing the [http://en.wikipedia.org/wiki/Hydrolysis hydrolysis] of fats/lipids which are consumed through oils. It is encoded by the [http://www.genecards.org/cgi-bin/carddisp.pl?gene=LPL p22 region in chromosome 8]. Once synthesized, it is secreted into the interstitial space in several tissues. The main site of action for <scene name='87/877513/Original_scene/1'>LPL</scene> is in the [http://www.pnas.org/content/pnas/116/5/1480/F1.large.jpg capillary lumen] within muscle and adipose tissues.<ref name=”Birrane”>PMID:30559189</ref> The function of this lipase is to hydrolyze [http://en.wikipedia.org/wiki/Triglyceride triglycerides] of very-low-density lipoproteins ([http://qph.fs.quoracdn.net/main-qimg-8e874e647baeb69b00203c47165247e2 VLDL]) and to aid in the delivery of lipid nutrients to vital tissues.<ref name=”Birrane”>PMID:30559189</ref> The enzyme is commonly found on the surface of cells that line blood capillaries. Two different lipoproteins are essential to break down triglycerides. One of them is utilized to transport fat into the bloodstream from different organs.<ref name=”Arora”>PMID:31072929</ref> A type of these lipoproteins, called [http://en.wikipedia.org/wiki/Chylomicron chylomicrons] are essential in the transport of long chain triglyceride from the small intestine to the tissues. The hydrolysis of triglycerides by lipoprotein lipase results in fat molecules being used by the body as energy or for storage in fatty tissue. <ref name=”Arora”>PMID:31072929</ref><ref name=”Mead”>PMID:12483461</ref>
==Structural Overview==
==Structural Overview==

Current revision

Lipoprotein Lipase coupled with GPIHBP1

Lipoprotein Lipase PDB

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

Maggie Stopa

Retrieved from "http://52.214.119.220/wiki/index.php/User:Maggie_Stopa/Sandbox_1"
Personal tools