1gsm

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<StructureSection load='1gsm' size='340' side='right'caption='[[1gsm]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
<StructureSection load='1gsm' size='340' side='right'caption='[[1gsm]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[1gsm]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GSM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1GSM FirstGlance]. <br>
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<table><tr><td colspan='2'>[[1gsm]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GSM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1GSM FirstGlance]. <br>
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</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1bqs|1bqs]]</div></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1gsm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1gsm OCA], [https://pdbe.org/1gsm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1gsm RCSB], [https://www.ebi.ac.uk/pdbsum/1gsm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1gsm ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1gsm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1gsm OCA], [https://pdbe.org/1gsm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1gsm RCSB], [https://www.ebi.ac.uk/pdbsum/1gsm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1gsm ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/MADCA_HUMAN MADCA_HUMAN]] Cell adhesion leukocyte receptor expressed by mucosal venules, helps to direct lymphocyte traffic into mucosal tissues including the Peyer patches and the intestinal lamina propria. It can bind both integrin alpha-4/beta-7 and L-selectin, regulating both the passage and retention of leukocytes. Isoform 2, lacking the mucin-like domain, may be specialized in supporting integrin alpha-4/beta-7-dependent adhesion strengthening, independent of L-selectin binding.
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[https://www.uniprot.org/uniprot/MADCA_HUMAN MADCA_HUMAN] Cell adhesion leukocyte receptor expressed by mucosal venules, helps to direct lymphocyte traffic into mucosal tissues including the Peyer patches and the intestinal lamina propria. It can bind both integrin alpha-4/beta-7 and L-selectin, regulating both the passage and retention of leukocytes. Isoform 2, lacking the mucin-like domain, may be specialized in supporting integrin alpha-4/beta-7-dependent adhesion strengthening, independent of L-selectin binding.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Brady, R L]]
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[[Category: Brady RL]]
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[[Category: Dando, J]]
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[[Category: Dando J]]
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[[Category: King, D J]]
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[[Category: King DJ]]
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[[Category: Ortlepp, S]]
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[[Category: Ortlepp S]]
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[[Category: Wilkinson, K W]]
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[[Category: Wilkinson KW]]
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[[Category: Cell adhesion glycoprotein]]
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[[Category: Cell adhesion protein]]
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[[Category: I-set fold]]
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[[Category: Immunoglobulin fold]]
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[[Category: Integrin recoginition]]
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[[Category: Madcam-1]]
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[[Category: Membrane protein]]
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Revision as of 12:05, 13 December 2023

A reassessment of the MAdCAM-1 structure and its role in integrin recognition.

PDB ID 1gsm

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OCA

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