1lu8

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==Solution structure of GsMTx-4==
==Solution structure of GsMTx-4==
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<StructureSection load='1lu8' size='340' side='right'caption='[[1lu8]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
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<StructureSection load='1lu8' size='340' side='right'caption='[[1lu8]]' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[1lu8]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LU8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1LU8 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[1lu8]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Grammostola_rosea Grammostola rosea]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LU8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1LU8 FirstGlance]. <br>
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</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1lu8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1lu8 OCA], [https://pdbe.org/1lu8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1lu8 RCSB], [https://www.ebi.ac.uk/pdbsum/1lu8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1lu8 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1lu8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1lu8 OCA], [https://pdbe.org/1lu8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1lu8 RCSB], [https://www.ebi.ac.uk/pdbsum/1lu8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1lu8 ProSAT]</span></td></tr>
</table>
</table>
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== Function ==
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[https://www.uniprot.org/uniprot/MTX4_GRARO MTX4_GRARO] This cationic hydrophobic peptide inhibits a lot of different channels and has an antimicrobial activity. It blocks mechanosensitive ion channels (also named stretch-activated channels or SACs), without having effect on whole-cell voltage-sensitive currents. Acts by partitioning into the membrane and perturbing the interface between the channel and the lipid bilayer without necessarily being in physical contact with the channel. Inhibits atrial fibrillation as well as the membrane motor of outer hair cells at low doses. It also binds to the voltage sensor of voltage-gated potassium channels from the archaebacterium Aeropyrum pernix (KvAP) without affecting channel gating. It has also a medium toxicity on a large spectra of sodium channels (Nav1.1/SCN1A, Nav1.2/SCN2A, Nav1.3/SCN3A, Nav1.4/SCN4A, Nav1.5/SCN5A, Nav1.6/SCN8A, Nav1.7/SCN9A), and also inhibits potassium channels Kv11.1/KCNH2 and Kv11.2/KCNH6. It also exhibits antimicrobial activities against the Gram-positive bacteria B.subtilis (MIC=0.5 uM), S.aureus (MIC=2-4 uM), and S.epidermidis (MIC=4-8 uM), and Gram-negative bacteria S.typhimurium (MIC=32.64 uM), P.aeruginosa (MIC=8-16 uM), and E.coli (MIC=8-16 uM).<ref>PMID:10779316</ref> <ref>PMID:11343101</ref> <ref>PMID:15241420</ref> <ref>PMID:15287735</ref> <ref>PMID:16376854</ref> <ref>PMID:16797839</ref> <ref>PMID:17384064</ref> <ref>PMID:17573432</ref> <ref>PMID:19955179</ref>
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== References ==
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<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Grammostola rosea]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Earm, Y E]]
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[[Category: Earm YE]]
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[[Category: Jung, H J]]
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[[Category: Jung HJ]]
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[[Category: Kim, J I]]
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[[Category: Kim JI]]
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[[Category: Lee, C W]]
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[[Category: Lee CW]]
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[[Category: Inhibitory cystine knot]]
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[[Category: Toxin]]
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[[Category: Triple stranded antiparellel beta-sheet]]
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Revision as of 18:48, 29 November 2023

Solution structure of GsMTx-4

PDB ID 1lu8

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