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Helicase 3D structures

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Line 32: Line 32:
**[[2is4]], [[2is6]] - EcHel II (mutant) + ADP + DNA<BR />
**[[2is4]], [[2is6]] - EcHel II (mutant) + ADP + DNA<BR />
**[[4c2t]], [[4c2u]], [[4c30]] – DrHel II + DNA - ''Deinococcus radiodurans''<br />
**[[4c2t]], [[4c2u]], [[4c30]] – DrHel II + DNA - ''Deinococcus radiodurans''<br />
-
**[[6ppj]] – MsHel (mutant) – ''Mycobacterium smegmatis'' – Cryo EM<br />
+
**[[6ppj]], [[7lhl]] – MsHel (mutant) – ''Mycobacterium smegmatis'' – Cryo EM<br />
**[[6ppr]], [[6ppu]] – MsHel + DNA – Cryo EM<br />
**[[6ppr]], [[6ppu]] – MsHel + DNA – Cryo EM<br />
 +
**[[6yi2]] – EcHel 645-720 - NMR<br />
*ATP-dependent helicase ATRX
*ATP-dependent helicase ATRX
Line 100: Line 101:
**[[5o6b]], [[5o6d]] – yPIF residues 237-780 + DNA + ATP<br />
**[[5o6b]], [[5o6d]] – yPIF residues 237-780 + DNA + ATP<br />
**[[5o6e]] – yPIF residues 237-780 + DNA + ADP<br />
**[[5o6e]] – yPIF residues 237-780 + DNA + ADP<br />
 +
**[[6s3e]], [[7ada]] – ToPIF residues 64-507 – ''Thermus oshimai''<br />
 +
**[[6xzt]] – ToPIF (mutant)<br />
 +
**[[6s3p]], [[7bil]] – ToPIF + DNA<br />
 +
**[[6s3h]], [[6s3i]], [[6s3m]], [[6s3n]], [[6s3o]] – ToPIF + DNA + ADP<br />
 +
**[[6l3g]] – PIF + DNA + ADP - ''Bacterioides''<br />
 +
**[[7otj]] – PIF + DNA + ADP – ''Candida albicans''<br />
*ATP-dependent DNA helicase TA0057
*ATP-dependent DNA helicase TA0057
Line 125: Line 132:
**[[2e29]], [[2m3d]] - hDDX50 GUCT domain - NMR<BR />
**[[2e29]], [[2m3d]] - hDDX50 GUCT domain - NMR<BR />
**[[1vec]] – hP54 N terminal<BR />
**[[1vec]] – hP54 N terminal<BR />
-
**[[3fho]] – DBP5 – fission yeast<BR />
+
**[[3fho]] – Dbp5 – fission yeast<BR />
-
**[[2kbe]] – yDBP5 N terminal – NMR<BR />
+
**[[2kbe]] – yDbp5 N terminal – NMR<BR />
-
**[[2kbf]] - yDBP5 C terminal – NMR<BR />
+
**[[2kbf]] - yDbp5 C terminal – NMR<BR />
-
**[[3gfp]] - yDBP5 C-terminal<BR />
+
**[[3gfp]] - yDbp5 C-terminal<BR />
-
**[[2hjv]] – BsDBPA domain 2 – ''Bacillus subtilis''<BR />
+
**[[2hjv]] – BsDbpA domain 2 – ''Bacillus subtilis''<BR />
-
**[[2g0c]] - BsDBPA RNA-binding domain<br />
+
**[[2g0c]] - BsDbpA RNA-binding domain<br />
**[[3eaq]], [[3ear]], [[3eas]] – TtHera residues 215-426 - ''Thermus thermophilus''<br />
**[[3eaq]], [[3ear]], [[3eas]] – TtHera residues 215-426 - ''Thermus thermophilus''<br />
**[[3i31]] - TtHera residues 431-517<br />
**[[3i31]] - TtHera residues 431-517<br />
Line 136: Line 143:
**[[3nej]] - TtHera N terminal (mutant)<br />
**[[3nej]] - TtHera N terminal (mutant)<br />
**[[5ivl]] – GsDB CSHA - ''Geobacillus stearothermophilus''<br />
**[[5ivl]] – GsDB CSHA - ''Geobacillus stearothermophilus''<br />
-
**[[5b88]] - EcDBP RRM-like domain - NMR<br />
+
**[[5b88]] - EcDbp RRM-like domain - NMR<br />
-
**[[5gju]] - EcDBP residues 6-210<br />
+
**[[5gju]] - EcDbp residues 6-210<br />
-
**[[5gi4]] - EcDBP residues 218-445<br />
+
**[[5gi4]] - EcDbp residues 218-445<br />
 +
**[[7bbb]] - EcDbpA residues 218-445 - NMR<br />
**[[6aib]] – SaDB CSHA N-terminal – ''Staphylococcus aureus''<br />
**[[6aib]] – SaDB CSHA N-terminal – ''Staphylococcus aureus''<br />
Line 191: Line 199:
**[[2rqa]] – hDHX58 C terminal – NMR<br />
**[[2rqa]] – hDHX58 C terminal – NMR<br />
**[[3vyx]], [[3vyy]] – hDHX9 RNA-binding domain + RNA<br />
**[[3vyx]], [[3vyy]] – hDHX9 RNA-binding domain + RNA<br />
 +
**[[6q6r]] – hDHX36 G-quadruplex domain + DNA <br />
**[[2n21]] – hDHX36 G-quadruplex domain + DNA - NMR<br />
**[[2n21]] – hDHX36 G-quadruplex domain + DNA - NMR<br />
**[[5e3h]] - hDHX58 residues 232-925 + RNA<br />
**[[5e3h]] - hDHX58 residues 232-925 + RNA<br />
Line 198: Line 207:
**[[5vhe]] – bDHX36 residues 56-1010 + DNA<br />
**[[5vhe]] – bDHX36 residues 56-1010 + DNA<br />
**[[2rs6]], [[2rs7]] – mDHX9 RNA-binding domain – NMR<br />
**[[2rs6]], [[2rs7]] – mDHX9 RNA-binding domain – NMR<br />
-
**[[6heg]], [[6eud]] – EcHRPB<br />
+
**[[6up4]] – mDHX36 + ADP <br />
 +
**[[7dcq]] – yPrp2 – Cryo EM<br />
 +
**[[7dcr]] – yPrp2 + Spp2 – Cryo EM<br />
 +
**[[7dd3]] – yPrp2 + Spp2 + RNA – Cryo EM<br />
 +
**[[7dcp]] – yPrp2 + Spp2 + ADP – Cryo EM<br />
 +
**[[6zwx]] – EcHrpA<br />
 +
**[[7akp]] – EcHrpA (mutant)<br />
 +
**[[6zww]] – EcHrpA + RNA<br />
 +
**[[6heg]], [[6eud]] – EcHrpB + ADP<br />
*ATP-dependent RNA helicase
*ATP-dependent RNA helicase
Line 265: Line 282:
**[[3vyx]], [[3vyy]] - hHel A RNA-binding domain + RNA<br />
**[[3vyx]], [[3vyy]] - hHel A RNA-binding domain + RNA<br />
**[[1whq]], [[2rs6]], [[2rs7]] – Hel A RNA-binding domain – mouse - NMR<BR />
**[[1whq]], [[2rs6]], [[2rs7]] – Hel A RNA-binding domain – mouse - NMR<BR />
 +
 +
*ATP-dependent RNA helicase Rep
 +
 +
**[[7lar]], [[7las]] – Rep + DNA + ADP – Porcine circovirus – Cryo EM<br />
*ATP-dependent RNA helicase Repa
*ATP-dependent RNA helicase Repa
Line 325: Line 346:
**[[2ztc]], [[2ztd]], [[2zte]], [[2h5x]] – MtRuvA – ''Mycobacterium tuberculosis''<BR />
**[[2ztc]], [[2ztd]], [[2zte]], [[2h5x]] – MtRuvA – ''Mycobacterium tuberculosis''<BR />
-
**[[7oa5]] - RuvA – ''Mycobacterium leprae''<BR />
+
**[[7oa5]] - MlRuvA – ''Mycobacterium leprae''<BR />
 +
**[[7oa5]] - MlRuvA + DNA<br />
**[[1cuk]], [[1hjp]] – EcRuvA<br />
**[[1cuk]], [[1hjp]] – EcRuvA<br />
**[[1d8l]] – EcRuvA N terminal<BR />
**[[1d8l]] – EcRuvA N terminal<BR />
Line 393: Line 415:
**[[1b79]] - EcDnaB N terminal<BR />
**[[1b79]] - EcDnaB N terminal<BR />
**[[1jwe]] - EcDnaB N terminal - NMR<BR />
**[[1jwe]] - EcDnaB N terminal - NMR<BR />
 +
**[[6kza]] - EcDnaB C terminal + DnaC<br />
**[[2r6c]], [[2r6a]] – BsDnaB + DnaG helicase-binding domain<br />
**[[2r6c]], [[2r6a]] – BsDnaB + DnaG helicase-binding domain<br />
**[[6bs8]], [[6own]] – MsDnaB 238-376<br />
**[[6bs8]], [[6own]] – MsDnaB 238-376<br />
**[[6rix]], [[6riy]] – DnaB (mutant) – ''Mycobacterium chimaera''<br />
**[[6rix]], [[6riy]] – DnaB (mutant) – ''Mycobacterium chimaera''<br />
 +
**[[6own]], [[6bs8]] – MsDnaB 238-376<br />
 +
**[[6t66]] – DnaB + GDP – Vibrio cholerae<br />
*DnaC helicase
*DnaC helicase
Line 403: Line 428:
**[[3ec2]] – AaDnaC – ''Aquifex aeolicus''<br />
**[[3ec2]] – AaDnaC – ''Aquifex aeolicus''<br />
**[[3ecc]] – AaDnaC + ADP<br />
**[[3ecc]] – AaDnaC + ADP<br />
-
**[[6qel]] – EcDnaC + replicative DNA Hel <br />
+
**[[6qel]] – EcDnaC + replicative DNA Hel - Cryo EM<br />
-
**[[6qem]] – EcDnaC + replicative DNA Hel + DNA<br />
+
**[[6qem]] – EcDnaC + replicative DNA Hel + DNA - Cryo EM<br />
*Helicase BLM
*Helicase BLM
Line 416: Line 441:
**[[4w7s]] – yCa8<br />
**[[4w7s]] – yCa8<br />
-
*Helicase NSP
+
*Helicase NSP see [[Nonstructural protein]]
-
 
+
-
**[[6jim]] – NSP2 + RNA – Chicungunya virus<br />
+
-
**[[2hwk]] – NSP2 – Venzuelan equine encephalitis virus<br />
+
-
**[[6jyt]], [[6zsl]] – NSP13 – Human SARS-COV virus<br />
+
*Helicase SEN1
*Helicase SEN1
**[[5mzn]], [[6i59]] – ySEN1<br />
**[[5mzn]], [[6i59]] – ySEN1<br />
 +
**[[6o3w]], [[6o3x]], [[6o3y]] – ySEN1 + Nrd1<br />
*Helicase DING
*Helicase DING
Line 454: Line 476:
**[[5ivw]] - hXPD + XPB + TFIIH ubunits 2,3,4,5 + SCP-X + SCP-Ybr />
**[[5ivw]] - hXPD + XPB + TFIIH ubunits 2,3,4,5 + SCP-X + SCP-Ybr />
-
*Pre-mRNA-splicing Helicase
+
*Pre-mRNA-splicing Helicase or Brr2
 +
**[[6s8o]] – hBrr2 394-2136 (mutant)<br />
 +
**[[6s8q]], [[6s9i]] – hBrr2 394-2136 + pre-mRNA-splicing factor 8<br />
 +
**[[7bdi]], [[7bdj]], [[7bdk]], [[7bdl]] – hBrr2 394-2136 + pre-mRNA-splicing factor 8 + nucleotide<br />
**[[3hib]], [[3im1]], [[3im2]] – yBrr2 2nd SEC63 domain<br />
**[[3hib]], [[3im1]], [[3im2]] – yBrr2 2nd SEC63 domain<br />
**[[4bgd]], [[5m5p]], [[5m52]], [[5dca]] – yBrr2 + pre-mRNA-splicing factor 8<br />
**[[4bgd]], [[5m5p]], [[5m52]], [[5dca]] – yBrr2 + pre-mRNA-splicing factor 8<br />
 +
**[[6qws]] – CtBrr2 <br />
 +
**[[6qv4]] – CtBrr2 + ATPgS<br />
*crispr-associated helicase Cas3
*crispr-associated helicase Cas3

Revision as of 07:50, 25 August 2021

3D structures of helicase

Updated on 25-August-2021

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Joel L. Sussman

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