Sandbox GGC6

Neurotrophin-4 (NT-4) is a neuronal growth factor that influences nerve cell proliferation through selective and non-covalent interactions with the nerve growth factor receptor. ^[1]

Function

NT-4 functions as a growth factor in many biological pathways and processes to induce neuronal proliferation. ^[2]

Biological Processes

Positive regulation of neurotrophin TRK receptor signaling pathway: NT-4 functions as a ligand when binding to neurotrophin receptor tyrosine kinase NTRK2. Auto-phosphorylated NTRK2 dimers that are formed on tyrosine residues in receptor tail as a result of NT-4 binding. Adult locomotory behavior ^[3], neuron projection morphogenesis: generating projection structures of a neuron, ^[4] ganglion mother cell fate determination,^[5] epidermis development, ^[6] innervation, long term memory, ^[7] chemical synaptic transmission modulation and nerve development, ^[8]

Disease

NT-4, along with other growth factors including neurotrophin-3 (NT-3), brain-derived neurotrophic factor (BDNF), and nerve growth factor (NGF) have all shown to be essential for survival of neurons. ^{[9] [10]} These growth factors have been associated with parts of the cerebrum including the frontal lobe and limbic system because of their involvement in neurological processes like behavior, learning, and memory. ^[11]

Relevance

Structural highlights

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