Sandbox GGC1

Kinesin is an ATP-dependent motor protein responsible for the transportation of cargo. It is a heterotetramer composed of light and heavy chains.

Function

• Moving cargo usually from the center of the cell to the margins
  
• Involved in cell replication and axonal signaling

Disease

• Charcot Marie Tooth (CMT): Charcot Marie Tooth is one of many diseases that affect the peripheral nervous system. Individuals may suffer physical disabilities due to weakness in transmission of signals firing from the central nervous system

Structural highlights

Scene #1

Kinesin structure is composed of eight anti-parallel Beta sheets and three alpha helices on opposite sides

Scene #2

This is the ATP binding site. Upon the binding of phosphate to ADP, ATP is formed giving Kinesin the energy needed to move the cargo one step a head to its destination

Scene #3

This is the Microtubule-binding site, where Kinesin binds to microtubules for stability

Scene #4

some patients with CMT show mutation in the p-loop. A missense mutation results in a leucine in place of glutamine affecting signal transmission

This is a sample scene created with SAT to by Group, and another to make of the protein. You can make your own scenes on SAT starting from scratch or loading and editing one of these sample scenes.