6wr0
From Proteopedia
(Difference between revisions)
| Line 1: | Line 1: | ||
==Human steroidogenic cytochrome P450 17A1 with 3-keto-delta4-abiraterone analog== | ==Human steroidogenic cytochrome P450 17A1 with 3-keto-delta4-abiraterone analog== | ||
| - | <StructureSection load='6wr0' size='340' side='right'caption='[[6wr0]]' scene=''> | + | <StructureSection load='6wr0' size='340' side='right'caption='[[6wr0]], [[Resolution|resolution]] 2.70Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6WR0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6WR0 FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[6wr0]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6WR0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6WR0 FirstGlance]. <br> |
| - | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6wr0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6wr0 OCA], [https://pdbe.org/6wr0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6wr0 RCSB], [https://www.ebi.ac.uk/pdbsum/6wr0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6wr0 ProSAT]</span></td></tr> | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.7Å</td></tr> |
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=U7P:(8alpha)-17-(pyridin-3-yl)androsta-4,16-dien-3-one'>U7P</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6wr0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6wr0 OCA], [https://pdbe.org/6wr0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6wr0 RCSB], [https://www.ebi.ac.uk/pdbsum/6wr0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6wr0 ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | == Disease == | ||
| + | [https://www.uniprot.org/uniprot/CP17A_HUMAN CP17A_HUMAN] Congenital adrenal hyperplasia due to 17-alpha-hydroxylase deficiency;46,XY disorder of sex development due to isolated 17, 20 lyase deficiency. The disease is caused by mutations affecting the gene represented in this entry. | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/CP17A_HUMAN CP17A_HUMAN] Conversion of pregnenolone and progesterone to their 17-alpha-hydroxylated products and subsequently to dehydroepiandrosterone (DHEA) and androstenedione. Catalyzes both the 17-alpha-hydroxylation and the 17,20-lyase reaction. Involved in sexual development during fetal life and at puberty.<ref>PMID:22266943</ref> | ||
| + | |||
| + | ==See Also== | ||
| + | *[[Cytochrome P450 3D structures|Cytochrome P450 3D structures]] | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Bart AG]] | [[Category: Bart AG]] | ||
[[Category: Petrunak EM]] | [[Category: Petrunak EM]] | ||
[[Category: Scott EE]] | [[Category: Scott EE]] | ||
Current revision
Human steroidogenic cytochrome P450 17A1 with 3-keto-delta4-abiraterone analog
| |||||||||||
