1ao7
From Proteopedia
(New page: 200px<br /> <applet load="1ao7" size="450" color="white" frame="true" align="right" spinBox="true" caption="1ao7, resolution 2.6Å" /> '''COMPLEX BETWEEN HUMA...) |
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| - | [[Image:1ao7.gif|left|200px]]<br /> | + | [[Image:1ao7.gif|left|200px]]<br /><applet load="1ao7" size="350" color="white" frame="true" align="right" spinBox="true" |
| - | <applet load="1ao7" size=" | + | |
caption="1ao7, resolution 2.6Å" /> | caption="1ao7, resolution 2.6Å" /> | ||
'''COMPLEX BETWEEN HUMAN T-CELL RECEPTOR, VIRAL PEPTIDE (TAX), AND HLA-A 0201'''<br /> | '''COMPLEX BETWEEN HUMAN T-CELL RECEPTOR, VIRAL PEPTIDE (TAX), AND HLA-A 0201'''<br /> | ||
==Overview== | ==Overview== | ||
| - | Recognition by a T-cell antigen receptor (TCR) of peptide complexed with a | + | Recognition by a T-cell antigen receptor (TCR) of peptide complexed with a major histocompatibility complex (MHC) molecule occurs through variable loops in the TCR structure which bury almost all the available peptide and a much larger area of the MHC molecule. The TCR fits diagonally across the MHC peptide-binding site in a surface feature common to all class I and class II MHC molecules, providing evidence that the nature of binding is general. A broadly applicable binding mode has implications for the mechanism of repertoire selection and the magnitude of alloreactions. |
==Disease== | ==Disease== | ||
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==About this Structure== | ==About this Structure== | ||
| - | 1AO7 is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Human_t-lymphotropic_virus_1 Human t-lymphotropic virus 1] with EMC as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http:// | + | 1AO7 is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Human_t-lymphotropic_virus_1 Human t-lymphotropic virus 1] with <scene name='pdbligand=EMC:'>EMC</scene> as [http://en.wikipedia.org/wiki/ligand ligand]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1AO7 OCA]. |
==Reference== | ==Reference== | ||
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[[Category: Human t-lymphotropic virus 1]] | [[Category: Human t-lymphotropic virus 1]] | ||
[[Category: Protein complex]] | [[Category: Protein complex]] | ||
| - | [[Category: Biddison, W | + | [[Category: Biddison, W E.]] |
| - | [[Category: Fan, Q | + | [[Category: Fan, Q R.]] |
| - | [[Category: Garboczi, D | + | [[Category: Garboczi, D N.]] |
[[Category: Ghosh, P.]] | [[Category: Ghosh, P.]] | ||
[[Category: Utz, U.]] | [[Category: Utz, U.]] | ||
| - | [[Category: Wiley, D | + | [[Category: Wiley, D C.]] |
[[Category: EMC]] | [[Category: EMC]] | ||
[[Category: class i mhc]] | [[Category: class i mhc]] | ||
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[[Category: viral peptide]] | [[Category: viral peptide]] | ||
| - | ''Page seeded by [http:// | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Feb 21 11:46:33 2008'' |
Revision as of 09:46, 21 February 2008
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COMPLEX BETWEEN HUMAN T-CELL RECEPTOR, VIRAL PEPTIDE (TAX), AND HLA-A 0201
Contents |
Overview
Recognition by a T-cell antigen receptor (TCR) of peptide complexed with a major histocompatibility complex (MHC) molecule occurs through variable loops in the TCR structure which bury almost all the available peptide and a much larger area of the MHC molecule. The TCR fits diagonally across the MHC peptide-binding site in a surface feature common to all class I and class II MHC molecules, providing evidence that the nature of binding is general. A broadly applicable binding mode has implications for the mechanism of repertoire selection and the magnitude of alloreactions.
Disease
Known diseases associated with this structure: Abacavir hypersensitivity, susceptibility to OMIM:[142800], Ankylosing spondylitis, susceptibility to, 1 OMIM:[142800], Hypoproteinemia, hypercatabolic OMIM:[109700], Stevens-Johnson syndrome, susceptibility to OMIM:[142800]
About this Structure
1AO7 is a Protein complex structure of sequences from Homo sapiens and Human t-lymphotropic virus 1 with as ligand. Full crystallographic information is available from OCA.
Reference
Structure of the complex between human T-cell receptor, viral peptide and HLA-A2., Garboczi DN, Ghosh P, Utz U, Fan QR, Biddison WE, Wiley DC, Nature. 1996 Nov 14;384(6605):134-41. PMID:8906788
Page seeded by OCA on Thu Feb 21 11:46:33 2008
