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2c97

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Current revision (14:09, 13 December 2023) (edit) (undo)
 
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<StructureSection load='2c97' size='340' side='right'caption='[[2c97]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
<StructureSection load='2c97' size='340' side='right'caption='[[2c97]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2c97]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/"bacillus_tuberculosis"_(zopf_1883)_klein_1884 "bacillus tuberculosis" (zopf 1883) klein 1884]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2C97 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2C97 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2c97]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis Mycobacterium tuberculosis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2C97 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2C97 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=DTD:DITHIANE+DIOL'>DTD</scene>, <scene name='pdbligand=JCL:4-(6-CHLORO-2,4-DIOXO-1,2,3,4-TETRAHYDROPYRIMIDIN-5-YL)+BUTYL+PHOSPHATE'>JCL</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1w19|1w19]], [[1w29|1w29]], [[2c92|2c92]], [[2c94|2c94]], [[2c9b|2c9b]], [[2c9d|2c9d]]</div></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=DTD:DITHIANE+DIOL'>DTD</scene>, <scene name='pdbligand=JCL:4-(6-CHLORO-2,4-DIOXO-1,2,3,4-TETRAHYDROPYRIMIDIN-5-YL)+BUTYL+PHOSPHATE'>JCL</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Riboflavin_synthase Riboflavin synthase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.5.1.9 2.5.1.9] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2c97 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2c97 OCA], [https://pdbe.org/2c97 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2c97 RCSB], [https://www.ebi.ac.uk/pdbsum/2c97 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2c97 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2c97 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2c97 OCA], [https://pdbe.org/2c97 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2c97 RCSB], [https://www.ebi.ac.uk/pdbsum/2c97 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2c97 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/RISB_MYCTU RISB_MYCTU]] Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin.<ref>PMID:15723519</ref>
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[https://www.uniprot.org/uniprot/RISB_MYCTU RISB_MYCTU] Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin.<ref>PMID:15723519</ref>
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Riboflavin synthase]]
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[[Category: Mycobacterium tuberculosis]]
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[[Category: Bacher, A]]
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[[Category: Bacher A]]
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[[Category: Cushman, M]]
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[[Category: Cushman M]]
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[[Category: Fischer, M]]
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[[Category: Fischer M]]
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[[Category: Haase, I]]
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[[Category: Haase I]]
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[[Category: Illarionov, B]]
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[[Category: Illarionov B]]
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[[Category: Jin, G]]
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[[Category: Jin G]]
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[[Category: Ladenstein, R]]
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[[Category: Ladenstein R]]
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[[Category: Morgunova, E]]
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[[Category: Morgunova E]]
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[[Category: Inhibitor binding]]
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[[Category: Riboflavin biosynthesis]]
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[[Category: Transferase]]
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Current revision

LUMAZINE SYNTHASE FROM MYCOBACTERIUM TUBERCULOSIS BOUND TO 4-(6- chloro-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl)butyl phosphate

PDB ID 2c97

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OCA

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