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2cih
From Proteopedia
(Difference between revisions)
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<StructureSection load='2cih' size='340' side='right'caption='[[2cih]], [[Resolution|resolution]] 1.50Å' scene=''> | <StructureSection load='2cih' size='340' side='right'caption='[[2cih]], [[Resolution|resolution]] 1.50Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[2cih]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/ | + | <table><tr><td colspan='2'>[[2cih]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2CIH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2CIH FirstGlance]. <br> |
| - | </td></tr><tr id=' | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.5Å</td></tr> |
| - | <tr id=' | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> |
| - | + | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2cih FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cih OCA], [https://pdbe.org/2cih PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2cih RCSB], [https://www.ebi.ac.uk/pdbsum/2cih PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2cih ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2cih FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2cih OCA], [https://pdbe.org/2cih PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2cih RCSB], [https://www.ebi.ac.uk/pdbsum/2cih PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2cih ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/FRIH_HUMAN FRIH_HUMAN] Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Has ferroxidase activity. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. Also plays a role in delivery of iron to cells. Mediates iron uptake in capsule cells of the developing kidney (By similarity). | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: | + | [[Category: Homo sapiens]] |
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[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: Crichton | + | [[Category: Crichton RR]] |
| - | [[Category: Declercq | + | [[Category: Declercq JP]] |
| - | [[Category: Toussaint | + | [[Category: Toussaint L]] |
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Current revision
Recombinant human H ferritin, K86Q and E27D mutant, soaked with Zn
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