2gb4
From Proteopedia
(Difference between revisions)
| Line 3: | Line 3: | ||
<StructureSection load='2gb4' size='340' side='right'caption='[[2gb4]], [[Resolution|resolution]] 1.25Å' scene=''> | <StructureSection load='2gb4' size='340' side='right'caption='[[2gb4]], [[Resolution|resolution]] 1.25Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[2gb4]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/ | + | <table><tr><td colspan='2'>[[2gb4]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2GB4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2GB4 FirstGlance]. <br> |
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SAH:S-ADENOSYL-L-HOMOCYSTEINE'>SAH</scene></td></tr> | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SAH:S-ADENOSYL-L-HOMOCYSTEINE'>SAH</scene></td></tr> | ||
| - | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Tpmt ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr> | ||
| - | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Thiopurine_S-methyltransferase Thiopurine S-methyltransferase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.1.67 2.1.1.67] </span></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2gb4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2gb4 OCA], [https://pdbe.org/2gb4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2gb4 RCSB], [https://www.ebi.ac.uk/pdbsum/2gb4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2gb4 ProSAT], [https://www.topsan.org/Proteins/JCSG/2gb4 TOPSAN]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2gb4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2gb4 OCA], [https://pdbe.org/2gb4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2gb4 RCSB], [https://www.ebi.ac.uk/pdbsum/2gb4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2gb4 ProSAT], [https://www.topsan.org/Proteins/JCSG/2gb4 TOPSAN]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
| - | + | [https://www.uniprot.org/uniprot/TPMT_MOUSE TPMT_MOUSE] Catalyzes the S-methylation of thiopurine drugs such as 6-mercaptopurine. | |
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
| Line 24: | Line 22: | ||
</StructureSection> | </StructureSection> | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: | + | [[Category: Mus musculus]] |
| - | + | ||
| - | + | ||
| - | + | ||
| - | + | ||
| - | + | ||
| - | + | ||
Revision as of 06:45, 25 January 2023
Crystal structure of Thiopurine methyltransferase (18204406) from Mus musculus at 1.35 A resolution
| |||||||||||
