7mm1
From Proteopedia
(Difference between revisions)
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==PTP1B in complex with TCS401 by Native S-SAD at Room Temperature== | ==PTP1B in complex with TCS401 by Native S-SAD at Room Temperature== | ||
| - | <StructureSection load='7mm1' size='340' side='right'caption='[[7mm1]]' scene=''> | + | <StructureSection load='7mm1' size='340' side='right'caption='[[7mm1]], [[Resolution|resolution]] 1.85Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7MM1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7MM1 FirstGlance]. <br> | + | <table><tr><td colspan='2'>[[7mm1]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7MM1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7MM1 FirstGlance]. <br> |
| - | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7mm1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7mm1 OCA], [https://pdbe.org/7mm1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7mm1 RCSB], [https://www.ebi.ac.uk/pdbsum/7mm1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7mm1 ProSAT]</span></td></tr> | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=OTA:2-(OXALYL-AMINO)-4,5,6,7-TETRAHYDRO-THIENO[2,3-C]PYRIDINE-3-CARBOXYLIC+ACID'>OTA</scene>, <scene name='pdbligand=TRS:2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>TRS</scene></td></tr> |
| + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[7l84|7l84]], [[7lvc|7lvc]]</div></td></tr> | ||
| + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">PTPN1, PTP1B ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr> | ||
| + | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Protein-tyrosine-phosphatase Protein-tyrosine-phosphatase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.3.48 3.1.3.48] </span></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7mm1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7mm1 OCA], [https://pdbe.org/7mm1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7mm1 RCSB], [https://www.ebi.ac.uk/pdbsum/7mm1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7mm1 ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | == Function == | ||
| + | [[https://www.uniprot.org/uniprot/PTN1_HUMAN PTN1_HUMAN]] Tyrosine-protein phosphatase which acts as a regulator of endoplasmic reticulum unfolded protein response. Mediates dephosphorylation of EIF2AK3/PERK; inactivating the protein kinase activity of EIF2AK3/PERK. May play an important role in CKII- and p60c-src-induced signal transduction cascades. May regulate the EFNA5-EPHA3 signaling pathway which modulates cell reorganization and cell-cell repulsion.<ref>PMID:21135139</ref> <ref>PMID:22169477</ref> | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| + | [[Category: Human]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: Dalton | + | [[Category: Protein-tyrosine-phosphatase]] |
| - | [[Category: Greisman | + | [[Category: Dalton, K M]] |
| - | [[Category: Hekstra | + | [[Category: Greisman, J B]] |
| + | [[Category: Hekstra, D R]] | ||
| + | [[Category: Hydrolase]] | ||
| + | [[Category: Hydrolase-hydrolase inhibitor complex]] | ||
| + | [[Category: Inhibitor]] | ||
| + | [[Category: Protein tyrosine phosphatase 1b]] | ||
Revision as of 09:31, 26 May 2021
PTP1B in complex with TCS401 by Native S-SAD at Room Temperature
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