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2jez

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Current revision (14:45, 13 December 2023) (edit) (undo)
 
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<StructureSection load='2jez' size='340' side='right'caption='[[2jez]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
<StructureSection load='2jez' size='340' side='right'caption='[[2jez]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2jez]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JEZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2JEZ FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2jez]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JEZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2JEZ FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=HLO:1-[({2,4-BIS[(E)-(HYDROXYIMINO)METHYL]PYRIDINIUM-1-YL}METHOXY)METHYL]-4-CARBAMOYLPYRIDINIUM'>HLO</scene>, <scene name='pdbligand=P6G:HEXAETHYLENE+GLYCOL'>P6G</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.6&#8491;</td></tr>
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<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=SUN:O-[(R)-(DIMETHYLAMINO)(ETHOXY)PHOSPHORYL]-L-SERINE'>SUN</scene></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=HLO:1-[({2,4-BIS[(E)-(HYDROXYIMINO)METHYL]PYRIDINIUM-1-YL}METHOXY)METHYL]-4-CARBAMOYLPYRIDINIUM'>HLO</scene>, <scene name='pdbligand=P6G:HEXAETHYLENE+GLYCOL'>P6G</scene>, <scene name='pdbligand=SUN:O-[(R)-(DIMETHYLAMINO)(ETHOXY)PHOSPHORYL]-L-SERINE'>SUN</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1c2b|1c2b]], [[1c2o|1c2o]], [[1j06|1j06]], [[1j07|1j07]], [[1ku6|1ku6]], [[1maa|1maa]], [[1mah|1mah]], [[1n5m|1n5m]], [[1n5r|1n5r]], [[1q83|1q83]], [[1q84|1q84]], [[2c0p|2c0p]], [[2c0q|2c0q]], [[2h9y|2h9y]], [[2ha0|2ha0]], [[2ha2|2ha2]], [[2ha3|2ha3]], [[2ha4|2ha4]], [[2ha5|2ha5]], [[2ha6|2ha6]], [[2ha7|2ha7]], [[2jf0|2jf0]], [[2jey|2jey]]</div></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2jez FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jez OCA], [https://pdbe.org/2jez PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2jez RCSB], [https://www.ebi.ac.uk/pdbsum/2jez PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2jez ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2jez FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jez OCA], [https://pdbe.org/2jez PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2jez RCSB], [https://www.ebi.ac.uk/pdbsum/2jez PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2jez ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/ACES_MOUSE ACES_MOUSE]] Terminates signal transduction at the neuromuscular junction by rapid hydrolysis of the acetylcholine released into the synaptic cleft.
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[https://www.uniprot.org/uniprot/ACES_MOUSE ACES_MOUSE] Terminates signal transduction at the neuromuscular junction by rapid hydrolysis of the acetylcholine released into the synaptic cleft.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Lk3 transgenic mice]]
 
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[[Category: Astot, C]]
 
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[[Category: Ekstrom, F]]
 
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[[Category: Pang, Y P]]
 
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[[Category: Acetylcholinesterase]]
 
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[[Category: Alternative splicing]]
 
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[[Category: Glycoprotein]]
 
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[[Category: Hlo-7]]
 
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[[Category: Hydrolase]]
 
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[[Category: Membrane]]
 
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[[Category: Mouse]]
 
[[Category: Mus musculus]]
[[Category: Mus musculus]]
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[[Category: Neurotransmitter degradation]]
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[[Category: Astot C]]
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[[Category: Oxime]]
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[[Category: Ekstrom F]]
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[[Category: Serine esterase]]
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[[Category: Pang YP]]
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[[Category: Synapse]]
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[[Category: Tabun]]
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Current revision

Mus musculus acetylcholinesterase in complex with tabun and HLo-7

PDB ID 2jez

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