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1o3r

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Current revision (23:45, 27 December 2023) (edit) (undo)
 
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<StructureSection load='1o3r' size='340' side='right'caption='[[1o3r]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
<StructureSection load='1o3r' size='340' side='right'caption='[[1o3r]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[1o3r]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1db8 1db8]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1O3R OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1O3R FirstGlance]. <br>
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<table><tr><td colspan='2'>[[1o3r]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1db8 1db8]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1O3R OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1O3R FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CMP:ADENOSINE-3,5-CYCLIC-MONOPHOSPHATE'>CMP</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1o3q|1o3q]], [[1o3s|1o3s]], [[1o3t|1o3t]]</div></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CMP:ADENOSINE-3,5-CYCLIC-MONOPHOSPHATE'>CMP</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1o3r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1o3r OCA], [https://pdbe.org/1o3r PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1o3r RCSB], [https://www.ebi.ac.uk/pdbsum/1o3r PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1o3r ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1o3r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1o3r OCA], [https://pdbe.org/1o3r PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1o3r RCSB], [https://www.ebi.ac.uk/pdbsum/1o3r PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1o3r ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[https://www.uniprot.org/uniprot/CRP_ECOLI CRP_ECOLI]] This protein complexes with cyclic AMP and binds to specific DNA sites near the promoter to regulate the transcription of several catabolite-sensitive operons. The protein induces a severe bend in the DNA. Acts as a negative regulator of its own synthesis as well as for adenylate cyclase (cyaA), which generates cAMP.<ref>PMID:2982847</ref>
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[https://www.uniprot.org/uniprot/CRP_ECOLI CRP_ECOLI] This protein complexes with cyclic AMP and binds to specific DNA sites near the promoter to regulate the transcription of several catabolite-sensitive operons. The protein induces a severe bend in the DNA. Acts as a negative regulator of its own synthesis as well as for adenylate cyclase (cyaA), which generates cAMP.<ref>PMID:2982847</ref>
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Bacillus coli migula 1895]]
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[[Category: Escherichia coli]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Berman, H M]]
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[[Category: Berman HM]]
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[[Category: Chen, S]]
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[[Category: Chen S]]
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[[Category: Ebright, R H]]
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[[Category: Ebright RH]]
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[[Category: Parkinson, G N]]
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[[Category: Parkinson GN]]
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[[Category: Vojtechovsky, J]]
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[[Category: Vojtechovsky J]]
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[[Category: Camp receptor protein]]
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[[Category: Cap]]
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[[Category: Cap-dna]]
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[[Category: Catabolite gene activator protein]]
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[[Category: Crp]]
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[[Category: Gene regulation-dna complex]]
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[[Category: Protein-dna complex]]
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Current revision

PROTEIN-DNA RECOGNITION AND DNA DEFORMATION REVEALED IN CRYSTAL STRUCTURES OF CAP-DNA COMPLEXES

PDB ID 1o3r

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