1efd

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{{STRUCTURE_1efd| PDB=1efd | SCENE= }}
{{STRUCTURE_1efd| PDB=1efd | SCENE= }}
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'''PERIPLASMIC FERRIC SIDEROPHORE BINDING PROTEIN FHUD COMPLEXED WITH GALLICHROME'''
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===PERIPLASMIC FERRIC SIDEROPHORE BINDING PROTEIN FHUD COMPLEXED WITH GALLICHROME===
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==Overview==
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Siderophore binding proteins play a key role in the uptake of iron in many gram-positive and gram-negative bacteria. FhuD is a soluble periplasmic binding protein that transports ferrichrome and other hydroxamate siderophores. The crystal structure of FhuD from Escherichia coli in complex with the ferrichrome homolog gallichrome has been determined at 1.9 inverted question mark resolution, the first structure of a periplasmic binding protein involved in the uptake of siderophores. Gallichrome is held in a shallow pocket lined with aromatic groups; Arg and Tyr side chains interact directly with the hydroxamate moieties of the siderophore. FhuD possesses a novel fold, suggesting that its mechanisms of ligand binding and release are different from other structurally characterized periplasmic ligand binding proteins.
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(as it appears on PubMed at http://www.pubmed.gov), where 10742172 is the PubMed ID number.
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{{ABSTRACT_PUBMED_10742172}}
==About this Structure==
==About this Structure==
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[[Category: Fhud complex with gallichrome]]
[[Category: Fhud complex with gallichrome]]
[[Category: Periplasmic binding protein-siderophore complex]]
[[Category: Periplasmic binding protein-siderophore complex]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May 2 15:01:45 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 1 00:36:40 2008''

Revision as of 21:36, 30 June 2008

Image:1efd.png

Template:STRUCTURE 1efd

PERIPLASMIC FERRIC SIDEROPHORE BINDING PROTEIN FHUD COMPLEXED WITH GALLICHROME

Template:ABSTRACT PUBMED 10742172

About this Structure

1EFD is a Single protein structure of sequence from Escherichia coli. Full crystallographic information is available from OCA.

Reference

The structure of the ferric siderophore binding protein FhuD complexed with gallichrome., Clarke TE, Ku SY, Dougan DR, Vogel HJ, Tari LW, Nat Struct Biol. 2000 Apr;7(4):287-91. PMID:10742172

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